Results 231 to 240 of about 244,384 (286)

Matrix Metalloproteinase Inhibitors as Investigative Tools in the Pathogenesis and Management of Vascular Disease

Experientia. Supplementum, 2012
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various components of the extracellular matrix (ECM). MMPs could also regulate the activity of several non-ECM bioactive substrates, and consequently affect different cellular ...
M. M. Benjamin, R. Khalil
semanticscholar   +1 more source

Matrix metalloproteinases and metalloproteinase inhibitors in human interphotoreceptor matrix and vitreous

Current Eye Research, 1998
We wished to establish which matrix metalloproteinases (MMPs) and metalloproteinase inhibitors (TIMPs) were present in human interphotoreceptor matrix (IPM) and vitreous.IPM and vitreous were obtained from postmortem human eyebank eyes. Western immunoblots were probed with antibodies against human MMPs and TIMPs.
J J, Plantner, A, Smine, T A, Quinn
openaire   +2 more sources

Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

Critical Reviews™ in Eukaryotic Gene Expression, 1997
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
openaire   +2 more sources

New Heteroarylbenzenesulfonamides as Matrix Metalloproteinase Inhibitors.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Frédéric, Delbecq, Guy, Cordonnier, Nicole, Pommery, Didier, Barbry, Jean-Pierre, Hénichart   +4 more
openaire   +2 more sources

Selective matrix metalloproteinase inhibitors

2017
The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke,
CHANG MAYLAND, MOBASHERY SHAHRIAR
openaire   +6 more sources

Metalloproteinases and their inhibitors in matrix remodeling

Trends in Genetics, 1990
The matrix metalloproteinases are a tightly regulated family of enzymes that degrade extracellular matrix and basement membrane components. Recent evidence suggests that these proteases and their specific inhibitors play important roles in normal developmental processes and in pathological conditions.
openaire   +2 more sources

The Regulation of Neovascularization by Matrix Metalloproteinases and Their Inhibitors

STEM CELLS, 1997
The process of new capillary formation from preexisting vessels, angiogenesis, is a complex physiological event which is strictly controlled, occurring only very rarely under normal conditions. In contrast, there are a number of serious diseases, among them solid tumor growth, rheumatoid arthritis and several eye diseases, which are characterized by ...
openaire   +2 more sources

Inhibitors of Matrix Metalloproteinases

2002
Matrix metalloproteinases are a family of closely related enzymes that degrade extracellular-matrix proteins. All members of the family contain a zinc-binding catalytic domain and are active at neutral pH. A generic domain structure is shown in Fig. 1.
Peter D Brown, William G Stetler-Stevenson   +1 more
openaire   +1 more source

Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations

Science, 2002
L. Coussens, B. Fingleton, L. Matrisian
semanticscholar   +1 more source

Novel Matrix Metalloproteinase-9 (MMP-9) Inhibitors in Cancer Treatment

International Journal of Molecular Sciences, 2023
Sanaa Bardaweel
exaly