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Machine-Learning Approach to Identify Tissue Inhibitors of Metalloproteinases (TIMP) and Clinical Variables Predicting Executive Phenotypes in HIV-infected Adults. [PDF]

Open Forum Infect Dis
Weng YW, Tsai HC, Lee SS, Hsu CH, Lin SH.   +4 more
europepmc   +1 more source

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Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer

Seminars in Oncology, 2002
Preclinical studies have provided evidence that matrix metalloproteinases (MMPs), a family of zinc-containing proteolytic enzymes, facilitate tumor invasion, the establishment of metastases, and the promotion of tumor-related angiogenesis. Matrix metalloproteinase inhibitors (MMPIs) have been shown to inhibit tumor growth and dissemination in ...
P. Bonomi
openaire   +3 more sources

Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury☆

Human Pathology, 2006
The objective of this study was to assess matrix metalloproteinase (MMP) and MMP inhibitor expression in the airspace of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) and to determine the prognostic significance of MMP expression in this patient population.
Suzanne E G, Fligiel, Theodore, Standiford, Helene M, Fligiel, Donald, Tashkin, Robert M, Strieter, Roscoe L, Warner, Kent J, Johnson, James, Varani   +7 more
openaire   +3 more sources

Design and Therapeutic Application of Matrix Metalloproteinase Inhibitors

Chemical Reviews, 1999
A J Gearing, Mark Whittaker, Andrew J H Gearing   +2 more
exaly   +2 more sources

Docking studies of matrix metalloproteinase inhibitors: zinc parameter optimization to improve the binding free energy prediction

Journal of Molecular Graphics and Modelling, 2003
Xin Hu, W. Shelver
exaly   +2 more sources

Matrix metalloproteinase inhibitors

Investigational New Drugs, 1997
The matrix metalloproteinases (MMPs) are a family of at least fifteen secreted and membrane-bound zinc-endopeptidases. Collectively, these enzymes can degrade all of the components of the extracellular matrix, including fibrallar and non-fibrallar collagens, fibronectin, laminin and basement membrane glycoproteins.
S M, Wojtowicz-Praga, R B, Dickson, M J, Hawkins   +2 more
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Novel matrix metalloproteinase inhibitors: an updated patent review (2014 - 2020)

Expert Opinion on Therapeutic Patents, 2021
Introduction: Matrix MetalloProteinases (MMPs) are key enzymes in several pathophysiological processes connected to the extracellular matrix (ECM) degradation. Earlier clinical trials evaluating broad spectrum MMP inhibitors as cancer therapeutics failed
E. Lenci, Lucrezia Cosottini, A. Trabocchi   +2 more
semanticscholar   +1 more source