Results 221 to 230 of about 244,384 (286)

MATRIX METALLOPROTEINASE INHIBITORS

Experientia. Supplementum, 2012
KHERA MANOJ KUMAR, SATTIGERI JITENDRA, SATTIGERI VISWAJANANI, YADAV NEERAJ KUMAR, KUMAR KEWAL, RAUF ABDUL REHMAN ABDUL, CLIFFE IAN A, BHATNAGAR PRADIP KUMAR, RAY ABHIJIT, SRIVASTAVA PUNIT, DASTIDAR SUNANDA GHOSH   +10 more
semanticscholar   +8 more sources

Matrix metalloproteinase inhibitors

Current Oncology Reports, 2004
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are associated with the tumorigenic process. MMPs degrade the extracellular matrix, promoting tumor invasion and metastasis. They also regulate host defense mechanisms and normal cell function; blocking all MMPs may not lead to a positive therapeutic outcome. Most clinical
GAINES SIMON, HOLMES IAN PETER, WATSON STEPHEN PAUL   +2 more
openaire   +7 more sources

The Matrix Metalloproteinases and Their Inhibitors

American Journal of Respiratory Cell and Molecular Biology, 1992
Abstract A number of metalloproteinases that degrade the extracellular matrix of connective tissues and two specific tissue inhibitors of metalloproteinases (TIMPs) have now been isolated, characterized, and cloned. Comparison of the enzyme sequences has allowed the delineation of domain structures, and initial studies have been ...
G, Murphy, A J, Docherty
openaire   +2 more sources

The past, present and future perspectives of matrix metalloproteinase inhibitors.

Pharmacology and Therapeutics, 2019
Matrix metalloproteinases (MMPs) are a large family of enzymes that degrade the extracellular matrix (ECM). Under pathologic conditions, overexpression of MMPs or insufficient control by tissue inhibitors of MMPs (TIMPs) results in the dysregulation of ...
Kang Li, F. Tay, C. Yiu
semanticscholar   +1 more source

Matrix Metalloproteinase Inhibitors

BioDrugs, 1998
The matrix metalloproteinases (MMPs) are a family of closely related, zinc-dependent proteolytic enzymes. Collectively, they are capable of degrading all the components of the extracellular matrix and as such are involved in a number of physiological and pathological processes.
S A, Watson, G, Tierney
openaire   +2 more sources

Matrix metalloproteinases and inhibitors in dentistry

Clinical Oral Investigations, 2019
Matrix metalloproteinase (MMP) expression has been associated with tissue development, invasive cancer cell behavior, and inflammation. The associations of increased expression of MMPs with diseases have led to intensive research activities to develop MMP inhibitors.
Gerd-Jan Boelen, Lucas Boute, Joëy d’Hoop, Mostafa EzEldeen, Ivo Lambrichts, Ghislain Opdenakker   +5 more
openaire   +2 more sources

Fluorinated Inhibitors of Matrix Metalloproteinases

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Viani F, Bruché L, Candiani G, Huguenot F, Jagodzinska M, Maffezzoni R, Moussier N, Sani M, Sinisi R, Zanda M   +9 more
openaire   +3 more sources

Matrix Metalloproteinases and Their Inhibitors

2001
Matrix metalloproteinases (MMPs) are a group of 16 enzymes that are capable of degrading extracellular matrix components. Their catalytic function is dependent on a zinc ion in the active center. MMPs are separated in three groups: gelatinases (type IV-collagenases), stromelysins, and interstitial collagenases.
A, Kugler, P, Thelen, R H, Ringert
openaire   +2 more sources

Inhibitors of matrix metallaproteinases

2006
The present invention provides novel compounds of formulas I-IX, as described herein. Also provided are compositions of compounds of formulas I-IX, methods of making compounds of formulas I-IX, and methods of using compounds of formulas I-IX. The compounds of the invention can be used to inhibit matrix metalloproteinases, and are useful to treat ...
LEE MIJOON, IKEJIRI MASAHIRO, CHANG MAYLAND, FRIDMAN RAFAEL, MOBASHERY SHAHRIAR   +4 more
openaire   +4 more sources

Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease

2021
Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov, Marta, Kalousová, Tomáš, Zima, Vladimír, Tesař   +3 more
openaire   +2 more sources