Results 61 to 70 of about 125,678 (300)

Proteolysis/antiproteolysis system in apparently healthy men and women of different ages

RUDN Journal of Medicine
Relevance. Aging is anatural biological process of aretrograde nature, during which there is an imbalance of all systems, including the matrix metalloproteinase (MMP) system and tissue inhibitors of matrix metalloproteinases (TIMP). And vascular aging is
Vladimir N. Yushchuk, Natalia S. Chepurnova, Elena V. Markelova, Marina Z. Ermolitskaya, Anastacia Yu. Savchenko, Ivan N. Zakharov, Ksenia A. Andrushchenko, Polina V. Barabash, Yang Jia Xing, Daria A. Meshcheryakova, Natalia G. Plekhova   +10 more
doaj   +1 more source

Emerging pharmacological treatments to prevent abdominal aortic aneurysm growth and rupture [PDF]

, 2015
Abdominal aortic aneurysm (AAA) is a local expansion of the abdominal aorta wall caused by a complex multifactorial maladaptive vascular remodeling. Despite recent advances in the management of cardiovascular diseases, there currently is no established ...
Fraga-Silva, Rodrigo, Stergiopulos, Nikolaos, Trachet, Bram   +2 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

MT1-MMP as a Key Regulator of Metastasis

Cells, 2023
Membrane type1-matrix metalloproteinase (MT1-MMP) is a member of metalloproteinases that is tethered to the transmembrane. Its major function in cancer progression is to directly degrade the extracellular matrix components, which are mainly type I–III ...
Noritaka Tanaka, Takeharu Sakamoto
doaj   +1 more source

Inhibition of interleukin-1β-stimulated collagenase and stromelysin expression in human tendon fibroblasts by epigallocatechin gallate ester [PDF]

, 2004
The medicinal benefits of green tea (Camellia sinensis) consumption have been attributed to bioavailable polyphenols, notably epigallocatechin gallate (EGCG).
Buttle, David J., Corps, Anthony N., Curry, Valerie A., Hazleman, Brian L., Riley, Graham P.   +4 more
core   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Neuropsychotoxicity of Abused Drugs: Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine-Induced Behavioral Sensitization and Reward in Rodents

Journal of Pharmacological Sciences, 2008
Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) function to remodel the pericellular environment. We have investigated the role of the MMP/ TIMP system in methamphetamine (METH) dependence in rodents, in which the remodeling of neural ...
Hiroyuki Mizoguchi, Kiyofumi Yamada, Toshitaka Nabeshima   +2 more
doaj   +1 more source

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]

, 2012
Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos, Bartel, Behrens, Brew, C. Ries, Chirco, Clevers, Dasse, Day, Egea, Fata, Goff, Guedez, Guo, Huang, Huang, Ivey, Jho, Jiang, John, Joyce, Jung, K. Kehe, Liu, M. Jochum, MacDonald, Martinez, N. Rieth, P. Neth, Peter, Pittenger, Prockop, Reynolds, S. Zahler, Schiltz, Shtutman, Singer, T. Popp, Takahashi, Taube, V. Egea, Wingfield, Yi   +42 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Plasma matrix metalloproteinases in neonates having surgery for congenital heart disease

Heart International, 2009
During cardiopulmonary-bypass matrix-metalloproteinases released may contribute to ventricular dysfunction. This study was to determine plasma matrix-metalloproteinases in neonates after cardiopulmonary-bypass and their relation to post-operative course.
David B. Ross, Richard Schulz, Po-Yin Cheung, Ivan M. Rebeyka, Rhonda J. Rosychuk, John Dyck, Ari R. Joffe, Christina Schulz   +7 more
doaj   +1 more source