Results 71 to 80 of about 665,812 (269)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Parent Lindbladians for matrix product density operators

Physical Review Research
Understanding quantum phases of matter is a fundamental goal in physics. For pure states, the representatives of phases are the ground states of locally interacting Hamiltonians, which are also renormalization fixed points (RFPs).
Yuhan Liu, Alberto Ruiz-de-Alarcón, Georgios Styliaris, Xiao-Qi Sun, David Pérez-García, J. Ignacio Cirac   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Variational matrix product states for combinatorial optimization

Physical Review Research
To compute approximate solutions for combinatorial optimization problems, we describe variational methods based on the product state (PS) and matrix product state (MPS) ansätze.
Guillermo Preisser, Conor Mc Keever, Michael Lubasch   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

On the numerical ranges of matrix products

Applied Mathematics Letters, 2010
Let \(M_n\) denote the space of complex \(n\times n\) matrices, and let~\(A,B,C\in M_n\). The \(C\)-numerical range of~\(A\) is defined by \(W_C(A)=\{\mathrm{tr}\,(CU^*AU):\,U\in M_n\, \mathrm{is\,unitary}\}\). The authors study the equation (1)~\(W_C(AB)=W_C(BA)\). First, they prove this if \(A\) and \(B\) are symmetric and \(C\) is normal.
Mao-Ting Chien, Chung-Lien Ko, Hiroshi Nakazato   +2 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Products of commutators in matrix rings

Canadian Mathematical Bulletin
AbstractLet R be a ring and let $n\ge 2$ . We discuss the question of whether every element in the matrix ring $M_n(R)$ is a product of (additive) commutators $[x,y]=xy-yx$ , for $x,y\in M_n(R)$ . An example showing that this does not always hold, even when R is commutative, is provided.
Matej Brešar, Eusebio Gardella, Hannes Thiel   +2 more
openaire   +5 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Thermoplastic matrix towpreg production

Advances in Polymer Technology, 2010
AbstractThis work was carried out to establish the processing window for the cost‐efficient production of thermoplastic matrix towpregs with a recently developed powder‐coating equipment. Three different fiber‐reinforced thermoplastic matrix systems were studied: one for highly demanding markets (carbon fiber/Primospire™) and other two for commercial ...
Silva, J. F., Nunes, J. P., Velosa, J. C., Bernardo, C. A., Marques, A. T.   +4 more
openaire   +2 more sources