Results 71 to 80 of about 710,317 (313)

Dense QCD2 with matrix product states

Journal of High Energy Physics
We study one-flavor SU(2) and SU(3) lattice QCD in (1 + 1) dimensions at zero temperature and finite density using matrix product states and the density matrix renormalization group.
Tomoya Hayata, Yoshimasa Hidaka, Kentaro Nishimura   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Ubiquitous Sparse Matrix-Matrix Products

CoRR
Multiplication of a sparse matrix with another (dense or sparse) matrix is a fundamental operation that captures the computational patterns of many data science applications, including but not limited to graph algorithms, sparsely connected neural networks, graph neural networks, clustering, and many-to-many comparisons of biological sequencing data ...
openaire   +2 more sources

Product recommendation based on Matrix Factorization

, 2023
<p><strong><em>Abstract</em>— </strong><strong>The sparsity of user-product rating matrices poses a challenge for recommendation models based on matrix factorization (MF).
Jobin T J, Amal K Jose
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Tensor quantum programming

New Journal of Physics
Running quantum algorithms often involves implementing complex quantum circuits with such a large number of multi-qubit gates that the challenge of tackling practical applications appears daunting.
A Termanova, Ar Melnikov, E Mamenchikov, N Belokonev, S Dolgov, A Berezutskii, R Ellerbrock, C Mansell, M R Perelshtein   +8 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Efficiently Correcting Matrix Products [PDF]

, 2014
We study the problem of efficiently correcting an erroneous product of two \(n\times n\) matrices over a ring. We provide a randomized algorithm for correcting a matrix product with \(k\) erroneous entries running in \(\tilde{O}(\sqrt{k}n^2)\) time and a deterministic \(\tilde{O}(kn^2)\)-time algorithm for this problem (where the notation \(\tilde{O}\)
Leszek Gasieniec, Christos Levcopoulos, Andrzej Lingas   +2 more
openaire   +1 more source

Testing of a Structures Covariance Matrix for Three-Level Repeated Measures Data. [PDF]

This paper considers the problem of estimating, and testing for, a Kronecker product covariance structure of three-level (multiple time points (p), multiple sites (u), and multiple response variables (q)) multivariate data.
Ricardo Leiva, Anuradha Roy
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source