Results 81 to 90 of about 710,317 (313)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Nonconventional random matrix products
Electronic Communications in Probability, 2018 Let $ξ_1,ξ_2,...$ be independent identically distributed random variables and $F:\bbR^\ell\to SL_d(\bbR)$ be a Borel measurable matrix-valued function.
Kifer, Y, SODIN, A
openaire +3 more sources
Identifying and evaluating parallel design activities using the design structure matrix
, 2005 This paper describes an approach based upon the Design Structure Matrix (DSM) for identifying, evaluating and optimising one aspect of CE: activity parallelism.
Whitfield, R.I. +2 more
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Continuous Matrix Product States for Quantum Fields [PDF]
, 2010 We define matrix product states in the continuum limit, without any reference to an underlying lattice parameter. This allows us to extend the density matrix renormalization group and variational matrix product state formalism to quantum field theories ...
Verstraete, F. +5 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Light-cone matrix product [PDF]
Journal of Mathematical Physics, 2009 We show how to combine the light-cone and matrix product algorithms to simulate quantum systems far from equilibrium for long times. For the case of the XXZ spin chain at Δ=0.5, we simulate to a time of ≈22.5. While part of the long simulation time is due to the use of the light-cone method, we also describe a modification of the infinite time-evolving
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
SINGULAR RANDOM MATRIX DECOMPOSITIONS: JACOBIANS. [PDF]
For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L´U, L´DM and modified QR (QDR).
Graciela González-Farías +1 more
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The Product Piracy Conflict Matrix – Central Element of an Integrated, TRIZ-based Approach to Technology-based Know-how Protection [PDF]
, 2009 Organised by: Cranfield UniversityThe paper gives a general introduction to product piracy as an economic and a methodological challenge. Technology-based know-how protection is presented and its potentials outlined.
Schuh, G. +3 more
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