Results 81 to 90 of about 4,993,076 (256)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pearson product-moment correlation matrix for flux data.

, 2020
Pearson product-moment correlation matrix for flux data.
Lee W. Cooper (8748120), Chelsea Wegner Koch (8748117), Thomas A. Brown (272386), Karen E. Frey (8748123), Jacqueline M. Grebmeier (8748126), Catherine Lalande (8695653)   +5 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SINGULAR RANDOM MATRIX DECOMPOSITIONS: JACOBIANS. [PDF]

For a singular random matrix Y, we find the Jacobians associated with the following decompositions; QR, Polar, Singular Value (SVD), L´U, L´DM and modified QR (QDR).
Graciela González-Farías, José A. Díaz-García   +1 more
core  

Matrix product operator representations [PDF]

, 2010
We show how to construct relevant families of matrix product operators (MPOs) in one and higher dimensions. These form the building blocks for the numerical simulation methods based on matrix product states and projected entangled pair states.
Murg, V., Verstraete, F., Murg, V, Cirac, JI, Pirvu, B., Verstraete, Frank, Cirac, J., Pirvu, B   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Adjacency Matrix of Product of Graphs

In graph theory, different types of matrices associated with graph, e.g. Adjacency matrix, Incidence matrix, Laplacian matrix etc. Among all adjacency matrix play an important role in graph theory.
Urvashi Acharya, Himali Mehta
core   +1 more source

Variational matrix product states for combinatorial optimization

Physical Review Research
To compute approximate solutions for combinatorial optimization problems, we describe variational methods based on the product state (PS) and matrix product state (MPS) ansätze.
Guillermo Preisser, Conor Mc Keever, Michael Lubasch   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parent Lindbladians for matrix product density operators

Physical Review Research
Understanding quantum phases of matter is a fundamental goal in physics. For pure states, the representatives of phases are the ground states of locally interacting Hamiltonians, which are also renormalization fixed points (RFPs).
Yuhan Liu, Alberto Ruiz-de-Alarcón, Georgios Styliaris, Xiao-Qi Sun, David Pérez-García, J. Ignacio Cirac   +5 more
doaj   +1 more source