Results 71 to 80 of about 4,695,396 (296)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Matrix Production, Pigment Synthesis, and Sporulation in a Marine Isolated Strain of Bacillus pumilus

Marine Drugs, 2015
The ability to produce an extracellular matrix and form multicellular communities is an adaptive behavior shared by many bacteria. In Bacillus subtilis, the model system for spore-forming bacteria, matrix production is one of the possible differentiation
Blanda Di Luccia, Antonio Riccio, Adele Vanacore, Loredana Baccigalupi, Antonio Molinaro, Ezio Ricca   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Application Level Synthesis: Creating Matrix-Matrix Multiplication Library: A Case Study

IEEE Access
Efficiently synthesizing an entire application that consists of multiple algorithms for hardware implementation is a very difficult and unsolved problem. One of the main challenges is the lack of good algorithmic libraries.
Dhilleswararao Pudi, Yu Yang, Dimitrios Stathis, Sunil Kumar Prajapati, Srinivas Boppu, Ahmed Hemani, Linga Reddy Cenkeramaddi   +6 more
doaj   +1 more source

Metal Matrix Composites Reinforced by Nano-Particles—A Review

Metals, 2014
Metal matrix composites reinforced by nano-particles are very promising materials, suitable for a large number of applications. These composites consist of a metal matrix filled with nano-particles featuring physical and mechanical properties very ...
Riccardo Casati, Maurizio Vedani
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Mechanisms balancing skeletal matrix synthesis and degradation [PDF]

Biochemical Journal, 2002
Bone is regulated by evolutionarily conserved signals that balance continuous differentiation of bone matrix-producing cells against apoptosis and matrix removal. This is continued from embryogenesis, where the skeleton differentiates as a solid mass and is shaped into separate bones by cell death and proteolysis.
Harry C, Blair, Mone, Zaidi, Paul H, Schlesinger   +2 more
openaire   +2 more sources

Lossy Coupling Matrix Synthesis Approach for the Realization of Negative Group Delay Response

IEEE Access, 2018
In this paper, a systematic synthesis approach is proposed for achieving negative group delay responses using lossy coupling matrix. It is mathematically proved that, for a passive and reciprocal network, loss is the necessary condition to realize a ...
Ranjan Das, Qingfeng Zhang, Haiwen Liu
doaj   +1 more source

Quantifying Cell‐Derived Changes in Collagen Synthesis, Alignment, and Mechanics in a 3D Connective Tissue Model

Advanced Science, 2022
Dysregulation of extracellular matrix (ECM) synthesis, organization, and mechanics are hallmark features of diseases like fibrosis and cancer. However, most in vitro models fail to recapitulate the three‐dimensional (3D) multi‐scale hierarchical ...
Benjamin T. Wilks, Elisabeth B. Evans, Andrew Howes, Caitlin M. Hopkins, Morcos N. Nakhla, Geoffrey Williams, Jeffrey R. Morgan   +6 more
doaj   +1 more source