Results 1 to 10 of about 41,616 (114)

Periodic Mechanical Stress Inhibits the Development of Osteoarthritis via Regulating ATF3-Akt Axis [PDF]

Journal of Inflammation Research, 2023
Yi Lou,1,2,* Fanglong Song,3,* Yifan Kang,2 Yaozeng Xu1 1Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China; 2Department of Orthopaedics, Shanghai Eastern Hepatobiliary ...
Lou Y, Song F, Kang Y, Xu Y
doaj   +2 more sources

Construction of tissue-engineered nucleus pulposus by stimulation with periodic mechanical stress and BMP-2 [PDF]

iScience, 2022
Summary: Intervertebral disc (IVD) degeneration, which is common among elderly individuals, mainly manifests as low back pain and is caused by structural deterioration of the nucleus pulposus (NP) due to physiological mechanical stress.
Yang Liu, Gong-ming Gao, Kai-yuan Yang, Lu-ming Nong   +3 more
doaj   +2 more sources

Periodic mechanical stress activates MEK1/2-ERK1/2 mitogenic signals in rat chondrocytes through Src and PLCγ1

Brazilian Journal of Medical and Biological Research, 2011
The mitogenic effects of periodic mechanical stress on chondrocytes have been studied extensively but the mechanisms whereby chondrocytes sense and respond to periodic mechanical stress remain a matter of debate.
Kewei Ren, Yimin Ma, Yumin Huang, Wenwei Liang, Feng Liu, Qing Wang, Weiding Cui, Zhengyu Liu, Guoyong Yin, Weimin Fan   +9 more
doaj   +3 more sources

Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells. [PDF]

J Mol Histol, 2023
Gao G, Ren K, Chen L, Li X, Li Z, Liu Y, Ouyang C, Wang H, Nong L, Xie H.   +9 more
europepmc   +2 more sources

Topology‐Enriched Toughness Enhancement in Quasi‐Periodic Metastructures Featuring Tailorable Strong‐Weak Network [PDF]

Advanced Science
Thin‐walled cellular structures deliver ultralow density and high specific strength for damage‐tolerant components. Yet periodic lattices may hard‐wire repeating weak features that promote tensile‐catastrophic fracture, whereas aperiodic networks erase ...
Tianyu Gao, Genda Wang, Jiabao Bai, Kai Liu   +3 more
doaj   +2 more sources

Impact of Geometry on the Thermal and Mechanical Properties of Periodic Surface Structures: A Numerical Study [PDF]

MATEC Web of Conferences, 2022
Periodic Surface Structures (PSS) fabricated via Additive Manufacturing (AM) have recently emerged as being appropriate candidates for high-value engineered structures.
Gawrońska Elżbieta, Dyja Robert
doaj   +1 more source

Theoretical model of homogenized piezoelectric materials with small non-collinear periodic cracks [PDF]

Fracture and Structural Integrity, 2017
An analytical model for the homogenization of a piezoelectric material with small periodic fissures is proposed on the basis of the method of asymptotic expansions for the elastic displacement, the electric scalar potential and the test functions ...
Jean-Marie Nianga, Driss Marhabi
doaj   +2 more sources

Periodic Mechanical Stress INDUCES Chondrocyte Proliferation and Matrix Synthesis via CaMKII-Mediated Pyk2 Signaling

Cellular Physiology and Biochemistry, 2017
Background/Aims: Periodic mechanical stress can promote chondrocyte proliferation and matrix synthesis to improve the quality of tissue-engineered cartilage. Although the integrin β1–ERK1/2 signal cascade has been implicated in periodic mechanical stress-
Wenwei Liang, Zeng Li, Zhen Wang, Jinchun Zhou, Huanghe Song, Shun Xu, Weiding Cui, Qing Wang, Zhefeng Chen, Feng Liu, Weimin Fan   +10 more
doaj   +1 more source

Periodic Mechanical Stress Stimulates the FAK Mitogenic Signal in Rat Chondrocytes Through ERK1/2 Activity

Cellular Physiology and Biochemistry, 2013
Background/Aims: The biological effects of periodic mechanical stress on chondrocytes have been studied extensively over the past few years. However, the mechanisms underlying chondrocyte mechanosensing and signaling in response to periodic mechanical ...
Wenwei Liang, Kewei Ren, Feng Liu, Weiding Cui, Qing Wang, Zhefeng Chen, Weimin Fan   +6 more
doaj   +1 more source

Periodic Mechanical Stress Activates PKCδ-Dependent EGFR Mitogenic Signals in Rat Chondrocytes via PI3K-Akt and ERK1/2

Cellular Physiology and Biochemistry, 2016
Background/Aims: The present study aimed to analyze the mechanisms by which periodic mechanical stress is translated into biochemical signals, and to verify the important role of signaling molecules including phosphatidylinositol-3-kinase (PI3K)-Akt ...
Peng He, Nan Shen, Gongming Gao, Xuefeng Jiang, Huiqing Sun, Dong Zhou, Nanwei Xu, Luming Nong, Kewei Ren   +8 more
doaj   +1 more source