Results 51 to 60 of about 329,808 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Measuring Sphericity in Positive Semi-Definite Matrices

open access: yesAxioms
The measure of sphericity for positive semi-definite matrices plays a crucial role in understanding their geometric properties, especially in high-dimensional settings.
Dário Ferreira, Sandra S. Ferreira
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Critical asymptotic behavior for the Korteweg–de Vries equation and in random matrix theory [PDF]

open access: yes, 2014
We discuss universality in random matrix theory and in the study of Hamiltonian partial differential equations. We focus on universality of critical behavior and we compare results in unitary random matrix ensembles with their coun- terparts for the ...
Claeys, T., Grava, Tamara
core  

Applications of interval matrices in power system stabilizer design

open access: yes, 1997
In this paper the robust stability analysis of a single machine infinite bus system is investigated using interval matrix theory. Specifically the parameters of the power system stabilizer are considered as uncertainties in the system A matrix. The range
Vournas, C. D.   +11 more
core   +1 more source

Theory of ion-matrix-sheath dynamics

open access: yesAIP Advances, 2018
The time evolution of a one-dimensional, uni-polar ion sheath (an “ion matrix sheath”) is investigated. The analytical solutions for the ion-fluid and Poisson’s equations are found for an arbitrary time dependence of the wall-applied ...
L. Kos, D. D. Tskhakaya
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Black Holes Hint towards De Sitter Matrix Theory

open access: yesUniverse, 2023
De Sitter black holes and other non-perturbative configurations can be used to probe the holographic degrees of freedom of de Sitter space. For small black holes, evidence was first provided in the seminal work of Banks, Fiol, and Morrise and follow-ups ...
Leonard Susskind
doaj   +1 more source

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