Results 41 to 50 of about 177,423,405 (278)

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Objective and Subjective Sleep Patterns in Adults with Maturity-Onset Diabetes of the Young (MODY)

, 2023
   Article highlights: a) To examine sleep patterns in patients with Maturity-Onset Diabetes of the Young. b) Are sleep disturbances common in Maturity-Onset Diabetes of the Young?
Louis H. Philipson (8561265), Maria V. Salguero (14280215), Kristen Wroblewski (614763), Esra Tasali (14280220), Rochelle N. Naylor (9140375), Marilyn Arosemena (14280206)   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

MODY: Strategies for a unique form of diabetes

Journal of Education and Health Promotion
Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant form of diabetes that typically presents before the age of 25. It is caused by mutations in single genes involved in insulin production and glucose regulation, leading to ...
Ram K. Garg
doaj   +1 more source

Update on clinical screening of maturity-onset diabetes of the young (MODY)

Diabetology & Metabolic Syndrome, 2020
Background Maturity-onset diabetes of the young (MODY) is the most common type of monogenic diabetes, being characterized by beta-cell disfunction, early onset, and autosomal dominant inheritance.
Renata Peixoto-Barbosa, André F. Reis, Fernando M. A. Giuffrida   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Molecular genetic analysis and clinical consideration of two families with GCK gene mutation [PDF]

Jichu yixue yu linchuang, 2020
Objective To explore the molecular genetics and clinical characteristics of two cases of maturity-onset diabetes of the young (MODY) type 2 caused by glucokinase (GCK) gene mutation.
WANG Zhi-xin, ZUO Qing-yao, LI Wei, CHEN Jia, DENG Wei
doaj  

Pathophysiology of diabetes: An overview

Avicenna Journal of Medicine, 2020
Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which results from abnormalities in either insulin secretion or insulin action or both ...
Mujeeb Z Banday, Aga S Sameer, Saniya Nissar   +2 more
doaj   +1 more source

Islet autoantibodies can discriminate maturity-onset diabetes of the young (MODY) from Type 1 diabetes

, 2011
AIM: Maturity-onset diabetes of the young is a monogenic form of familial, young-onset diabetes. It is rare (∼1% diabetes) and may be misdiagnosed as Type 1 diabetes and inappropriately treated with insulin.
Hattersley, AT, M. Shepherd, Shields, B, Shepherd, Maggie, Shields, Beverley, P. Bingley, Sian Ellard, A. Williams, McDonald, TJ, Bingley, P., Bingley, PJ, Williams, AJK, R. Brown, B. Shields, Hattersley, Andrew T., Brown, R. S., K. Colclough, Colclough, K, A. T. Hattersley, Williams, A. J., Brown, R, Colclough, K., T. J. McDonald, Ellard, S, Ellard, Sian, Shepherd, M, McDonald, Timothy J.   +26 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source