Results 91 to 100 of about 12,388,491 (323)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

A Rigidity Phenomenon for the Hardy-Littlewood Maximal Function

, 2014
The Hardy-Littlewood maximal function $\mathcal{M}$ and the trigonometric function $\sin{x}$ are two central objects in harmonic analysis. We prove that $\mathcal{M}$ characterizes $\sin{x}$ in the following way: let $f \in C^{\alpha}(\mathbb{R}, \mathbb{
S. Steinerberger
semanticscholar   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Matrix weights and a maximal function with exponent 3/2

Advanced Nonlinear Studies
We build an example of a simple sparse operator for which its norm with scalar A 2 weight has linear estimate in [w]A2 ${\left[w\right]}_{{A}_{2}}$ , but whose norm in matrix setting grows at least as [W]A23/2 ${\left[W\right]}_{{\mathbf{A}}_{2}}^{3/2}$
Treil Sergei, Volberg Alexander
doaj   +1 more source

Hölder Quasicontinuity in Variable Exponent Sobolev Spaces

Journal of Inequalities and Applications, 2007
We show that a function in the variable exponent Sobolev spaces coincides with a Hölder continuous Sobolev function outside a small exceptional set.
Katja Tuhkanen, Juha Kinnunen, Petteri Harjulehto   +2 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Two results on the value distribution of meromorphic functions

Open Mathematics
In this article, we prove two results on the value distribution of meromorphic functions. Using the theorem of Yamanoi, the first result gives a precise estimation of the relationship between the characteristic function of a meromorphic function and its ...
Yang Degui, He Zhiying, Liu Dan
doaj   +1 more source

Nonself-Adjoint Second-Order Difference Operators in Limit-Circle Cases

Abstract and Applied Analysis, 2012
We consider the maximal dissipative second-order difference (or discrete Sturm-Liouville) operators acting in the Hilbert space ℓ2𝑤(ℤ) (ℤ:={0,±1,±2,…}), that is, the extensions of a minimal symmetric operator with defect index (2,2) (in the Weyl ...
Bilender P. Allahverdiev
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source