Results 101 to 110 of about 777,151 (296)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

Calculation Method of Driving Force of the Plate Quantitative Conveyor Chain Drive System

open access: yesJixie chuandong, 2015
For improving the stability and security when the plate quantitative conveyor start-up and the accelerating operation,the calculation problem of driving force of chain drive system is studied.The maximum static tension of the chain drive system on stable
Xi Qiming   +3 more
doaj  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Acceleration of runaway electrons and Joule heating in solar flares [PDF]

open access: yes
The electric field acceleration of electrons out of a thermal plasma and the simultaneous Joule heating of the plasma are studied. Acceleration and heating timescales are derived and compared, and upper limits are obtained on the acceleration volume and ...
Holman, G. D.
core   +1 more source

Longitudinal Ion Acceleration from High-Intensity Laser Interactions with Underdense Plasma

open access: yes, 2007
Longitudinal ion acceleration from high-intensity (I ~ 10^20 Wcm^-2) laser interactions with helium gas jet targets (n_e ~ 0.04 n_c) have been observed.
Clarke, R. J.   +13 more
core   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

open access: yesFEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Test-retest and intrasession reliability of assisted sprint outcome measurements using a motorized resistance device

open access: yesFrontiers in Sports and Active Living
The aim of this study was to determine reliability of assisted sprint outcome measurements using a motorized resistance device (MRD). A total of 21 participants (16 males and 5 females; age 22.3 ± 3.9 years, body mass 75.2 ± 6.9 kg, height 177.9 ± 6.8 cm)
Ola Eriksrud, Frederic Westheim
doaj   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Enhancing proton acceleration by using composite targets

open access: yes, 2015
Efficient laser ion acceleration requires high laser intensities, which can only be obtained by tightly focusing laser radiation. In the radiation pressure acceleration regime, where the tightly focused laser driver leads to the appearance of the ...
Bulanov, S. S.   +7 more
core   +1 more source

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