Results 61 to 70 of about 777,151 (296)

The Principle of Maximum Acceleration

, 2019
In this microarticle, we analyze the physical interpretation of a maximum invariant acceleration.
openaire   +2 more sources

Diffusive Shock Acceleration with Magnetic Amplification by Non-resonant Streaming Instability in SNRs [PDF]

, 2008
We investigate the diffusive shock acceleration in the presence of the non-resonant streaming instability introduced by Bell (2004). The numerical MHD simulations of the magnetic field amplification combined with the analytical treatment of cosmic ray ...
Achterberg A., Axford W. I., Bell A. R., Bykov A. M., Dolginov A. Z., Gull S. F., Kontorovich V. M., Krymsky G. F., Livshits L. M., McKenzie J. F., Milne D. K., V. N. Zirakashvili, V. S. Ptuskin, Zirakashvili V. N.   +13 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Rapid Algorithm for Generating Entry Landing Footprints Satisfying the No-Fly Zone Constraint

International Journal of Aerospace Engineering, 2021
An online estimation algorithm of landing footprints based on the drag acceleration-energy profile is proposed for an entry hypersonic vehicle. Firstly, based on the Evolved Acceleration Guidance Logic for Entry (EAGLE), drag acceleration-energy profiles
Shengnan Fu, Tianyu Lu, Jian Yin, Qunli Xia   +3 more
doaj   +1 more source

Non-thermal particle acceleration from maximum entropy in collisionless plasmas

Journal of Plasma Physics, 2022
Dissipative processes cause collisionless plasmas in many systems to develop non-thermal particle distributions with broad power-law tails. The prevalence of power-law energy distributions in space/astrophysical observations and kinetic simulations of systems with a variety of acceleration and trapping (or escape) mechanisms poses a deep mystery.
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Optimization of Acceleration and Driving Force for Double-Toggle Stephenson-Chain Mold Clamping Mechanisms

Applied Sciences
The mold clamping mechanism is crucial in injection molding machines and significantly influences molding. This research optimizes the Stephenson-chain mechanism with double-toggle effects, particularly focusing on acceleration and driving force.
Tzu-Hsia Chen, Po-Cheng Lai
doaj   +1 more source

The Acceleration Mechanism of Resistive MHD Jets Launched from Accretion Disks

, 2004
We analyzed the results of non-linear resistive magnetohydrodynamical (MHD) simulations of jet formation to study the acceleration mechanism of axisymmetric, resistive MHD jets.
Abramowicz M., Blandford R. D., Kazunari Shibata, Kudoh T., Kudoh T., Kuwabara T., Ryoji Matsumoto, Shibata K., Takahiro Kudoh, Takuhito Kuwabara, Uchida Y.   +10 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source