Results 71 to 80 of about 777,151 (296)

The Influence of Different Driving Parameters on Traffic with a Cellular Automata Model

Applied Sciences
Reliable traffic simulations with high-quality results contribute to the understanding of the traffic system and effective planning. In this article, firstly, an existing cellular automata (CA) model is modified to perform a comprehensive analysis of the
Andrej Rigler, Goran Turk
doaj   +1 more source

Coulomb implosion mechanism of negative ion acceleration in laser plasmas

, 2008
Coulomb implosion mechanism of the negatively charged ion acceleration in laser plasmas is proposed. When a cluster target is irradiated by an intense laser pulse and the Coulomb explosion of positively charged ions occurs, the negative ions are ...
A. Yogo, A.S. Pirozhkov, A.Ya. Faenov, Bhardwaj, Borghesi, Bulanov, Bulanov, Bulanov, Clark, Denavit, Ditmire, Esirkepov, Flannery, Fuchs, Fukuda, Giulietti, Grisham, Gurevich, H. Daido, Hatchett, Inoue, Kando, Kar, Karsch, Kmetec, Last, Leemans, M. Kando, M. Tampo, Maksimchuk, Matsukado, Mora, Mourou, Nakamura, Nakamura, Nishihara, Passoni, Peart, Pegoraro, Petrov, Pirozhkov, Roth, S.V. Bulanov, Sarkisov, Schwoerer, Sedov, Silva, Smirnov, Snavely, Spencer, T. Kameshima, T. Nakamura, T.A. Pikuz, T.Zh. Esirkepov, Ta Phouc, Tabak, Ter-Avetisyan, Toncian, Volkov, Wei, Willingale, Y. Fukuda, Y. Hayashi, Yanovsky, Yin, Yogo   +65 more
core   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Numerical analysis of effective parameters in response of the nonlinear passive viscous systems [PDF]

Journal of Structural and Construction Engineering, 2017
In this article all the effective parameters in response of nonlinear passive viscous systems are investigated. Here, the term response is referred to the maximum inter-story drift and maximum absolute acceleration of the stories.
GholamReza Havaei, Alireza Zare
doaj   +1 more source

Propagating front in an excited granular layer

, 1998
A partial monolayer of ~ 20000 uniform spherical steel beads, vibrated vertically on a flat plate, shows remarkable ordering transitions and cooperative behavior just below 1g maximum acceleration.
A. Kudrolli, A. Lorenz, A. Puglisi, C. S. Campbell, D. G. W. Cooper, F. Gerl, G. Peng, H. M. Jaeger, H. M. Jaeger, I. Goldhirsch, J. P. Gollub, J. S. Olafsen, L. Labous, M. A. Hopkins, N. B. Tufillaro, S. Luding, S. McNamara, S. McNamara, S. Warr, T. A. Knight, W. Losert, Y. Du   +21 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Crossing the cosmological constant line in a dilatonic brane-world model with and without curvature corrections

, 2008
We construct a new brane-world model composed of a bulk -with a dilatonic field-, plus a brane -with brane tension coupled to the dilaton-, cold dark matter and an induced gravity term.
Antonio Ferrera, Bouhmadi-López M, Bouhmadi-López M, Bouhmadi-López M, Bowcock P, Cai R G, Cai R G, Chimento L P, de Rham C Dvali G Hofmann S Khoury J Pujolas O Redi M Tolley A J, Giannantonio T Scranton R Crittenden R G Nichol R C Boughn S P Myers A D Richards G T, Kiritsis E, Kofinas G, Komatsu E (WMAP Collaboration), Koyama K, Maartens R, Mariam Bouhmadi-López, Minamitsuji M, Papantonopoulos E, Perlmutter S, Riess A G, Sahni V, Spergel D N, Starobinsky A A   +22 more
core   +1 more source

Radiation from relativistic jets in turbulent magnetic fields [PDF]

, 2008
Using our new 3-D relativistic electromagnetic particle (REMP) code parallelized with MPI, we have investigated long-term particle acceleration associated with an relativistic electron-positron jet propagating in an unmagnetized ambient electron-positron
B. Zhang, Charles Meegan, Chryssa Kouveliotou, G. J. Fishman, H. Sol, J. Frederiksen, J. Niemiec, K.-I. Nishikawa, M. Medvedev, Neil Gehrels, P. Hardee, Y. Mizuno, Å. Nordlund   +12 more
core   +3 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source