Results 91 to 100 of about 1,156,434 (264)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Corrigendum to “Invertible Quadratic Non-Linear Layers for MPC-/FHE-/ZK-Friendly Schemes over Fnp : Application to Poseidon”

IACR Transactions on Symmetric Cryptology
Neptune is a hash function proposed by Grassi et al. at ToSC 2022(3) for Zero-Knowledge (ZK) applications. In this note, we show that the linear layer of Neptune’s external rounds fails to guarantee the maximum growth of the degree, potentially ...
Matilda Urani, Lorenzo Grassi
doaj   +1 more source

General scaling of maximum degree of synchronization in noisy complex networks

New Journal of Physics, 2014
The effects of white noise and global coupling strength on the maximum degree of synchronization in complex networks are explored. We perform numerical simulations of generic oscillator models with both linear and non-linear coupling functions on a broad
Dominik Traxl, Niklas Boers, Jürgen Kurths   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Disjoint subgraphs of large maximum degree

Discrete Mathematics, 2002
The authors study the minimum size \(b(n,m)\) of a graph \(G=(V,E)\) such that for every partition \(V=A\cup B\) either \(\Delta(G[A])\geq n\) or \(\Delta(G[B])\geq m\) and the minimum size \(q(n,j,l)\) of a graph \(G=(V,E)\) having \(n+j+l\) vertices such that \(\Delta(G[A])\geq n\) for every set \(A\subseteq V\) with \(|A|=n+j\).
Pikhurko, Oleg, Thomason, Andrew
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

On the Hypercompetition Numbers of Hypergraphs with Maximum Degree at Most Two

Discussiones Mathematicae Graph Theory, 2015
In this note, we give an easy and short proof for the theorem by Park and Kim stating that the hypercompetition numbers of hypergraphs with maximum degree at most two is at most two.
Sano Yoshio
doaj   +1 more source

Sum labelling graphs of maximum degree two

Discrete Mathematics
The concept of sum labelling was introduced in 1990 by Harary. A graph is a sum graph if its vertices can be labelled by distinct positive integers in such a way that two vertices are connected by an edge if and only if the sum of their labels is the label of another vertex in the graph.
Henning Fernau, Kshitij Gajjar
openaire   +2 more sources