Results 101 to 110 of about 8,396,712 (346)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Maximum principle and the fourth order boundary value problem

open access: yesMathematical Modelling and Analysis, 2011
This paper is devoted to the study the nonlinear boundary value problem . We state a maximum principle related with the operator  and apply it to prove the existence and approximation of solutions to the problem (i), (ii), in presence of properly ordered
Inara Yermachenko
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

The Maximum Principle for Optimal Control Problems with Time Delays

open access: yesSIAM Journal of Control and Optimization, 2017
: In this paper we present necessary conditions for optimal control problems with time delays. The dynamic constraint is formulated as a control delay differential equation, with time delays occuring in both state and control variables.
Andrea Boccia, R. Vinter
semanticscholar   +1 more source

A maximum principle for combinatorial Yamabe flow [PDF]

open access: yes, 2005
This article studies a discrete geometric structure on triangulated manifolds and an associated curvature flow (combinatorial Yamabe flow). The associated evolution of curvature appears to be like a heat equation on graphs, but it can be shown to not ...
Glickenstein, David, David Glickenstein
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Strong maximum principle for fractional diffusion equations and an application to an inverse source problem [PDF]

open access: yes, 2015
The strong maximum principle is a remarkable property of parabolic equations, which is expected to be partly inherited by fractional diffusion equations.
Yikan Liu, W. Rundell, Masahiro Yamamoto
semanticscholar   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Maximum principles at infinity and the Ahlfors-Khas'minskii duality

open access: yes, 2017
Maximum principles at infinity (or ``almost maximum principles") are a powerful tool to investigate the geometry of Riemannian manifolds. In this talk I will focus on the the Ekeland, the Omori-Yau principles and their weak versions, in the sense of ...
Mari, Luciano
core   +1 more source

Home - About - Disclaimer - Privacy