Results 41 to 50 of about 5,003,645 (342)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Remarks on comparison principles for -Laplacian with extension to -Laplacian

Bulletin of Mathematical Sciences
Our purpose is to generalize some recent comparison principles for operators driven by [Formula: see text]-Laplacian to a wide class of quasilinear equations including [Formula: see text]-Laplacian.
Ahmed Mohammed, Antonio Vitolo
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Maximum principles for a family of nonlocal boundary value problems

Advances in Difference Equations, 2004
We study a family of three-point nonlocal boundary value problems (BVPs) for an nth-order linear forward difference equation. In particular, we obtain a maximum principle and determine sign properties of a corresponding Green function.
Paul W. Eloe
doaj   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The effects of nonlinear perturbation terms on comparison principles for the -Laplacian

Bulletin of Mathematical Sciences
In this paper, we investigate various comparison principles for quasilinear elliptic equations of [Formula: see text]-Laplace type with lower-order terms that depend on the solution and its gradient.
Ahmed Mohammed, Antonio Vitolo
doaj   +1 more source

Some maximum principles for solutions of a class of partial differential equations in Ω⊂ℝn

International Journal of Mathematics and Mathematical Sciences, 2000
We find maximum principles for solutions of semilinear elliptic partial differential equations of the forms: (1) Δ2u+αf(u)=0, α∈ℝ+ and (2) ΔΔu+α(Δu)k+gu=0, α≤0 in some region Ω⊂ℝn.
Mohammad Mujalli Al-Mahameed
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Existence and localization of solutions for fourth-order boundary-value problems

Electronic Journal of Differential Equations, 2007
In this paper, we study the existence of solutions for the differential equation $$ u^{(4)}(t)=fig(t,u(t),u''(t)ig), $$ where $f$ satisfies one-sided Lipschitz conditions with respect to $u$ and $u''$, with periodic conditions or boundary conditions from
Luis Sanchez, Ricardo Enguica
doaj