Results 111 to 120 of about 1,263,980 (273)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Choosing the best model in the presence of zero trade: a fish product analysis [PDF]
, 2012 The purpose of the paper is to test the hypothesis that food safety (chemical) standards act as barriers to international seafood imports. We use zero-accounting gravity models to test the hypothesis that food safety (chemical) standards act as barriers ...
Hite, D., Tran, N., Wilson, N.
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Surface Water Infiltration in Loess Soils of the Lower Mississippi River Valley: An Emphasis on Land Use [PDF]
, 2016 The Alluvial Aquifer is the shallowest and most heavily used groundwater aquifer in the Lower Mississippi River Valley, particularly in the Delta region of eastern Arkansas.
Thompson, Matthew
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Modeling soil organic carbon change in croplands of China [PDF]
, 2003 Using 1990 conditions, we modeled carbon (C) and nitrogen (N) biogeochemical cycles in croplands of China (and, for comparison, the United States) to estimate the annual soil organic-carbon (SOC) balance for all cropland.
Frolking, Steve +7 more
core +1 more source
Critical Behavior of Period Doublings in Coupled Inverted Pendulums
, 1998 We study the critical behaviors of period doublings in N (N=2,3,4,...) coupled inverted pendulums by varying the driving amplitude $A$ and the coupling strength $c$. It is found that the critical behaviors depend on the range of coupling interaction.
Hu, Bambi, Kim, Sang-Yoon
core +1 more source