Results 71 to 80 of about 1,674,135 (182)

The Halogen Effect in [Cu(NHC)X] Compounds: A Case Study on the Anti‐Leishmania and Antiviral Activity of [Cu(IPr)X]

ChemistrySelect, Volume 10, Issue 31, August 15, 2025.
This study explores how changing halidesfrom Cl to Iinfluences ionic radius, antioxidant activity, and lipophilicity. These shifts significantly impact the biological potency of [Cu(IPr)X] compounds against Leishmania parasites and arboviruses. A strategic tweak in halogen identity paves the way for enhanced therapeutic performance in metal‐based drug ...
J. V. Fontes, M. E. F. Agnoli, G. Clauss, M. S. A. Garcia, A. V. P. Ferreira, G. A. Antoniucci, A. L. Costa‐Oliveira, A.C.G. Jardim, D. C. Miguel, C. Abbehausen   +9 more
wiley   +1 more source

Integrating Citizen Science and Remote Sensing Data to Identify Key Environmental Factors Influencing H5N1 Avian Influenza Virus Potential Spillover Risk in the Philippines

GeoHealth, Volume 9, Issue 8, August 2025.
Abstract Highly pathogenic avian influenza (HPAI) virus presents a serious threat to poultry and public health worldwide, with transmission dynamics shaped by avian migration patterns and environmental conditions. Recent outbreaks in the Philippines highlight the urgent need for effective control measures.
John Oliver Sayseng, Ting‐Wu Chuang
wiley   +1 more source

Vigilância sorológica para arbovírus em Juruti, Pará, Brasil Serological survey for arboviruses in Juruti, Pará State, Brazil

Cadernos de Saúde Pública, 2009
O objetivo foi avaliar a prevalência de anticorpos para arbovírus na área de influência do Projeto Juruti antes da exploração mineral local. Foram examinados 1.597 soros humanos e 85 de animais silvestres.
Ana Cecilia Ribeiro Cruz, Assis do Socorro Correa dos Prazeres, Eliana Colares Gama, Maxwell Furtado de Lima, Raimunda do Socorro Silva Azevedo, Lívia Medeiros Neves Casseb, Joaquim Pinto Nunes Neto, Lívia Carício Martins, Jannifer Oliveira Chiang, Sueli Guerreiro Rodrigues, Pedro Fernando da Costa Vasconcelos   +10 more
doaj   +1 more source

Seroprevalence of Chikungunya and O'nyong‐nyong Viruses in Senegal, West Africa

Journal of Medical Virology, Volume 97, Issue 3, March 2025.
ABSTRACT Arthritogenic alphaviruses such as chikungunya (CHIKV) and o'nyong‐nyong (ONNV) viruses have shown capacity to cause widespread epidemics, with recurrent and sporadic outbreaks occurring throughout sub‐Saharan Africa. We analyzed the seroprevalence for CHIKV and ONNV in 470 non‐febrile subjects from three regions in Senegal (Sindia, 2018 ...
Prince Baffour Tonto, Mouhamad Sy, Ibrahima Mbaye Ndiaye, Mariama Toure, Amy Gaye, Mariama Aidara, Amadou Moctar Mbaye, Abdoulaye Kane Dia, Mamadou Alpha Diallo, Jules Francois Gomis, Mamadou Samb Yade, Younous Diedhiou, Baba Dieye, Khadim Diongue, Mame Cheikh Seck, Aida S. Badiane, Bobby Brooke Herrera, Daouda Ndiaye   +17 more
wiley   +1 more source

Mayaro Virus Induction of Oxidative Stress is Associated With Liver Pathology in a Non-Lethal Mouse Model

Scientific Reports, 2019
Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear.
Camila Carla da Silva Caetano, Fernanda Caetano Camini, Letícia Trindade Almeida, Ariane Coelho Ferraz, Tales Fernando da Silva, Rafaela Lameira Souza Lima, Mayara Medeiros de Freitas Carvalho, Thalles de Freitas Castro, Cláudia Martins Carneiro, Breno de Mello Silva, Silvana de Queiroz Silva, José Carlos de Magalhães, Cintia Lopes de Brito Magalhães   +12 more
doaj   +1 more source

Alphavirus nsP2: A Multifunctional Regulator of Viral Replication and Promising Target for Anti‐Alphavirus Therapies

Reviews in Medical Virology, Volume 35, Issue 2, March 2025.
ABSTRACT Alphaviruses are re‐emerging vector‐born pathogens that cause arthralgia or encephalitic diseases on a global scale. While a vaccine against chikungunya virus was recently approved, no vaccines currently exist for other alphaviruses, nor are there antiviral drugs for the treatment of alphavirus infections. Alphaviruses have positive‐strand RNA
Sainan Wang, Suresh Mahalingam, Andres Merits   +2 more
wiley   +1 more source

Activating FcγRs on monocytes are necessary for optimal Mayaro virus clearance

bioRxiv
Mayaro virus (MAYV) is an emerging arbovirus. Previous studies have shown antibody Fc effector functions are critical for optimal monoclonal antibody-mediated protection against alphaviruses; however, the requirement of Fc gamma receptors (FcγRs) for ...
Megan M. Dunagan, Nathânia Dábilla, Colton McNinch, J. Brenchley, Patrick T. Dolan, J. M. Fox   +5 more
semanticscholar   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Mayaro Virus in Child with Acute Febrile Illness, Haiti, 2015

Emerging Infectious Diseases, 2016
Mayaro virus has been associated with small outbreaks in northern South America. We isolated this virus from a child with acute febrile illness in rural Haiti, confirming its role as a cause of mosquitoborne illness in the Caribbean region.
John Lednicky, Valery Madsen Beau De Rochars, Maha Elbadry, Julia Loeb, Taina Telisma, Sonese Chavannes, Gina Anilis, Eleonora Cella, Massimo Ciccozzi, Bernard Okech, Marco Salemi, J. Glenn Morris   +11 more
doaj   +1 more source

A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations

Advanced Science, Volume 11, Issue 43, November 20, 2024.
This research shows an example that reducing innate immunogenicity to increase payload protein expression of self‐amplifying RNA via a single mutation in the macrodomain. The mutant saRNA attenuates the activation of the double‐stranded RNA sensor as well as the downstream interferon response.
Yue Gong, Danni Yong, Gensheng Liu, Jiang Xu, Jun Ding, William Jia   +5 more
wiley   +1 more source