Results 81 to 90 of about 4,380 (198)

Chikungunya Virus: Unveiling Its Global Impact (2002–2024)

Interdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.
Chikungunya virus (CHIKV), an arbovirus transmitted by Aedes mosquitoes, has caused massive global epidemics, where it causes periodic outbreaks of febrile illness. In recent years, it has afflicted populations of Africa, South America, and Southeast Asia.
Rakhi Issrani, Hafiz Muhammad Zeeshan, Jawairia Javed, Faqeeha Javed, Abid Iqbal, Shahzad Ahmad, Muhammad Amber Fareed, Shazia Iqbal, Suraiya Saleem   +8 more
wiley   +1 more source

Unexpected arboviruses found in an epidemiological surveillance of acute tropical febrile syndrome in the department of Meta, Eastern Colombia

Journal of Infection and Public Health
Background: Nonspecific acute tropical febrile illnesses (NEATFI) are common in the Latin American tropics. Dengue, Chikungunya, Zika, Mayaro, and Usutu, among others, can coexist in the American tropics.
Liliana Sánchez-Lerma, Andres Rojas-Gulloso, Jorge Miranda, Vanesa Tique, Luz Helena Patiño, Derly Rodriguez, Verónica Contreras, Alberto Paniz-Mondolfi, Norma Pavas, Juan David Ramírez, Salim Mattar   +10 more
doaj   +1 more source

Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

Parasites & Vectors, 2014
Background The arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America.
Kassia C W Spindola, Naomi K Simas, Tiago S Salles, Marcelo D F de Meneses, Alice Sato, Davis Ferreira, Wanderson Romão, Ricardo M Kuster   +7 more
doaj   +1 more source

A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations

Advanced Science, Volume 11, Issue 43, November 20, 2024.
This research shows an example that reducing innate immunogenicity to increase payload protein expression of self‐amplifying RNA via a single mutation in the macrodomain. The mutant saRNA attenuates the activation of the double‐stranded RNA sensor as well as the downstream interferon response.
Yue Gong, Danni Yong, Gensheng Liu, Jiang Xu, Jun Ding, William Jia   +5 more
wiley   +1 more source

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector

Journal of Medical Virology, Volume 96, Issue 11, November 2024.
ABSTRACT Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re‐emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus−host−vector
Pallavi Rai, Emily M. Webb, Sally L. Paulson, Lin Kang, James Weger‐Lucarelli   +4 more
wiley   +1 more source

The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]

, 2016
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S, Farzan, Michael, Gorman, Matthew J, Hyde, Jennifer L, Poddar, Subhajit   +4 more
core   +2 more sources

Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity

Parasites & Vectors, 2014
Background The arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America. Recently, MAYV has attracted attention due to
Alda E dos Santos, Ricardo M Kuster, Kristie A Yamamoto, Tiago S Salles, Renata Campos, Marcelo DF de Meneses, Márcia R Soares, Davis Ferreira   +7 more
doaj   +1 more source

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 673-684, October 2024.
Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing. The use of animal models confronts hurdles related to ethical considerations and the successful translation of findings from animals to humans.
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani   +3 more
wiley   +1 more source

Human Antibody Responses to Emerging Mayaro Virus and Cocirculating Alphavirus Infections Examined by Using Structural Proteins from Nine New and Old World Lineages

mSphere, 2018
Mayaro virus (MAYV), Venezuelan equine encephalitis virus (VEEV), and chikungunya virus (CHIKV) are vector-borne alphaviruses that cocirculate in South America.
Jessica L. Smith, Christine L. Pugh, Emily D. Cisney, Sarah L. Keasey, Carolina Guevara, Julia S. Ampuero, Guillermo Comach, Doris Gomez, Margarita Ochoa-Diaz, Robert D. Hontz, Robert G. Ulrich   +10 more
doaj   +1 more source

Genomic and phenotypic characterization of the Oropouche virus strain implicated in the 2022–24 large‐scale outbreak in Brazil

Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Abstract The Orthobunyavirus oropoucheense species encompasses a group of arthropod‐borne zoonotic viruses transmitted by biting midges to animals including humans. Several large‐scale human outbreaks caused by the prototype member of this species, Oropouche virus (OROV) have been documented since the 1970s and were primarily confined to the Amazon ...
Elisa de A. N. Azevedo, Alexandre F. da Silva, Verônica G. da Silva, Lais C. Machado, Gustavo B. de Lima, Bruno I. M. Ishigami, Keilla M. Paz e Silva, Mayara M. de O. M. da Costa, Diego A. Falcão, Andreza P. Vasconcelos, Clintiano C. da Silva, Felipe G. Naveca, Matheus F. Bezerra, Tulio de L. Campos, Bartolomeu Acioli‐Santos, Marcelo H. S. Paiva, Clarice N. L. de Morais, Gabriel L. Wallau   +17 more
wiley   +1 more source