Results 81 to 90 of about 4,724 (240)

Essential role of the CCL2-CCR2 axis in Mayaro virus-induced disease [PDF]

, 2023
Franciele Martins Santos, Victor Rodrigues de Costa Melo, Simone de Araújo, Carla Daiane Ferreira de Sousa, Thaiane Pinto Moreira, Matheus Rodrigues Gonçalves, Anna Clara Paiva Menezes dos Santos, Heloísa Athayde Seabra Ferreira, Pedro Augusto Carvalho Costa, Breno Rocha Barrioni, Paula Bargi-Souza, Marivalda M. Pereira, Maurício Lacerda Nogueira, Danielle G. Souza, Pedro Pires Goulart Guimarães, Mauro Martins Teixeira, Celso Martins Queiroz‐Junior, Vivian Vasconcelos Costa   +17 more
openalex   +1 more source

Chikungunya Virus: Unveiling Its Global Impact (2002–2024)

Interdisciplinary Perspectives on Infectious Diseases, Volume 2025, Issue 1, 2025.
Chikungunya virus (CHIKV), an arbovirus transmitted by Aedes mosquitoes, has caused massive global epidemics, where it causes periodic outbreaks of febrile illness. In recent years, it has afflicted populations of Africa, South America, and Southeast Asia.
Rakhi Issrani, Hafiz Muhammad Zeeshan, Jawairia Javed, Faqeeha Javed, Abid Iqbal, Shahzad Ahmad, Muhammad Amber Fareed, Shazia Iqbal, Suraiya Saleem   +8 more
wiley   +1 more source

A Novel Self‐Amplifying mRNA with Decreased Cytotoxicity and Enhanced Protein Expression by Macrodomain Mutations

Advanced Science, Volume 11, Issue 43, November 20, 2024.
This research shows an example that reducing innate immunogenicity to increase payload protein expression of self‐amplifying RNA via a single mutation in the macrodomain. The mutant saRNA attenuates the activation of the double‐stranded RNA sensor as well as the downstream interferon response.
Yue Gong, Danni Yong, Gensheng Liu, Jiang Xu, Jun Ding, William Jia   +5 more
wiley   +1 more source

Effects of Chikungunya virus immunity on Mayaro virus disease and epidemic potential [PDF]

Scientific Reports, 2019
AbstractMayaro virus (MAYV) causes an acute febrile illness similar to that produced by chikungunya virus (CHIKV), an evolutionary relative in the Semliki Forest virus complex of alphaviruses. MAYV emergence is typically sporadic, but recent isolations and outbreaks indicate that the virus remains a public health concern.
Emily M. Webb, Sasha R. Azar, Sherry L. Haller, Rose M. Langsjoen, Candace E. Cuthbert, Anushka T. Ramjag, Huanle Luo, Kenneth Plante, Tian Wang, Graham Simmons, Christine V. F. Carrington, Scott C. Weaver, Shannan L. Rossi, Albert J. Auguste   +13 more
openaire   +2 more sources

Antiviral Activities of Silymarin and Derivatives

Molecules, 2019
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses,
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin   +3 more
doaj   +1 more source

HIV-1 pathogenicity and virion production are dependent on the metabolic phenotype of activated CD4+ T cells [PDF]

, 2014
BACKGROUND:HIV-1, like all viruses, is entirely dependent on the host cell for providing the metabolic resources for completion of the viral replication cycle and the production of virions.
Andrea Hegedus, Hendrik Huthoff, Maia Kavanagh Williamson   +2 more
core   +2 more sources

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector

Journal of Medical Virology, Volume 96, Issue 11, November 2024.
ABSTRACT Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re‐emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus−host−vector
Pallavi Rai, Emily M. Webb, Sally L. Paulson, Lin Kang, James Weger‐Lucarelli   +4 more
wiley   +1 more source

Unexpected arboviruses found in an epidemiological surveillance of acute tropical febrile syndrome in the department of Meta, Eastern Colombia

Journal of Infection and Public Health
Background: Nonspecific acute tropical febrile illnesses (NEATFI) are common in the Latin American tropics. Dengue, Chikungunya, Zika, Mayaro, and Usutu, among others, can coexist in the American tropics.
Liliana Sánchez-Lerma, Andres Rojas-Gulloso, Jorge Miranda, Vanesa Tique, Luz Helena Patiño, Derly Rodriguez, Verónica Contreras, Alberto Paniz-Mondolfi, Norma Pavas, Juan David Ramírez, Salim Mattar   +10 more
doaj   +1 more source

Anti-Mayaro virus activity of Cassia australis extracts (Fabaceae, Leguminosae)

Parasites & Vectors, 2014
Background The arthropod-borne Mayaro virus (MAYV) causes ‘Mayaro fever’, a disease of medical significance, primarily affecting individuals in permanent contact with forested areas in tropical South America.
Kassia C W Spindola, Naomi K Simas, Tiago S Salles, Marcelo D F de Meneses, Alice Sato, Davis Ferreira, Wanderson Romão, Ricardo M Kuster   +7 more
doaj   +1 more source

Characterization of Systemic Disease Development and Paw Inflammation in a Susceptible Mouse Model of Mayaro Virus Infection and Validation Using X-ray Synchrotron Microtomography [PDF]

, 2023
Ana Carolina de Carvalho, Carlos Sato Baraldi Dias, Laís D. Coimbra, Rebeca de Paiva Fróes Rocha, Alexandre Borin, Marina Alves Fontoura, Murilo de Carvalho, Paul Proost, Maurício Lacerda Nogueira, Sílvio Roberto Consonni, Renata Sesti‐Costa, Rafael Elias Marques   +11 more
openalex   +1 more source