Results 81 to 90 of about 1,674,135 (182)

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector

Journal of Medical Virology, Volume 96, Issue 11, November 2024.
ABSTRACT Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re‐emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus−host−vector
Pallavi Rai, Emily M. Webb, Sally L. Paulson, Lin Kang, James Weger‐Lucarelli   +4 more
wiley   +1 more source

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Animal Models and Experimental Medicine, Volume 7, Issue 5, Page 673-684, October 2024.
Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing. The use of animal models confronts hurdles related to ethical considerations and the successful translation of findings from animals to humans.
Megan Caifeng Tang, Ka Heng Wong, Adzzie Shazleen Azman, Rafidah Lani   +3 more
wiley   +1 more source

Chikungunya Virus Exposure Partially Cross-Protects against Mayaro Virus Infection in Mice

Journal of Virology, 2021
Mosquito-borne viruses have a worldwide impact, especially in tropical climates. Chikungunya virus has been present mostly in developing countries, causing millions of infections, while Mayaro virus, a close relative, has been limited to the Caribbean ...
M. Fumagalli, W. M. de Souza, L. A. de Castro-Jorge, R. V. D. de Carvalho, I. Castro, Luiz Gustavo Nogueira de Almeida, S. Consonni, D. Zamboni, L. T. Figueiredo   +8 more
semanticscholar   +1 more source

Genomic and phenotypic characterization of the Oropouche virus strain implicated in the 2022–24 large‐scale outbreak in Brazil

Journal of Medical Virology, Volume 96, Issue 10, October 2024.
Abstract The Orthobunyavirus oropoucheense species encompasses a group of arthropod‐borne zoonotic viruses transmitted by biting midges to animals including humans. Several large‐scale human outbreaks caused by the prototype member of this species, Oropouche virus (OROV) have been documented since the 1970s and were primarily confined to the Amazon ...
Elisa de A. N. Azevedo, Alexandre F. da Silva, Verônica G. da Silva, Lais C. Machado, Gustavo B. de Lima, Bruno I. M. Ishigami, Keilla M. Paz e Silva, Mayara M. de O. M. da Costa, Diego A. Falcão, Andreza P. Vasconcelos, Clintiano C. da Silva, Felipe G. Naveca, Matheus F. Bezerra, Tulio de L. Campos, Bartolomeu Acioli‐Santos, Marcelo H. S. Paiva, Clarice N. L. de Morais, Gabriel L. Wallau   +17 more
wiley   +1 more source

Alpha‐mannosidase‐2 modulates arbovirus infection in a pathogen‐ and Wolbachia‐specific manner in Aedes aegypti mosquitoes

Insect Molecular Biology, Volume 33, Issue 4, Page 362-371, August 2024.
Mosquito genetic background can modulate Wolbachia pathogen‐blocking phenotypes. The alpha‐mannosidase‐2 gene has previously been identified as a potential candidate. αMan2 CRISPR KO mutagenesis suppresses dengue virus titres but increases Mayaro virus titres, in Wolbachia‐uninfected mosquitoes.
Nadya Urakova, Renuka E. Joseph, Allyn Huntsinger, Vanessa M. Macias, Matthew J. Jones, Leah T. Sigle, Ming Li, Omar S. Akbari, Zhiyong Xi, Konstantinos Lymperopoulos, Richard T. Sayre, Elizabeth A. McGraw, Jason L. Rasgon   +12 more
wiley   +1 more source

Antiviral Activities of Silymarin and Derivatives

Molecules, 2019
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-inflammatory, and hepatoprotective functions. Recent studies have also documented the antiviral activities of silymarin and its derivatives against several viruses,
Ching-Hsuan Liu, Alagie Jassey, Hsin-Ya Hsu, Liang-Tzung Lin   +3 more
doaj   +1 more source

Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito‐borne viruses

Insect Science, Volume 31, Issue 3, Page 663-673, June 2024.
Mosquito salivary proteins (MSPs) bear multitudinous functions, embracing facilitating blood feeding and affecting the infection of mosquito‐borne viruses (MBVs) via directly interplaying with MBVs or tuning the homeostasis of host cells. In vivo, MSPs can modulate host's innate and adaptive immunity, which in turn impacts the native infection at the ...
Zhao‐Yang Wang, Kai‐Xiao Nie, Ji‐Chen Niu, Gong Cheng   +3 more
wiley   +1 more source

Mayaro Fever Virus, Brazilian Amazon

Emerging Infectious Diseases, 2009
In February 2008, a Mayaro fever virus (MAYV) outbreak occurred in a settlement in Santa Barbara municipality, northern Brazil. Patients had rash, fever, and severe arthralgia lasting up to 7 days.
Raimunda S.S. Azevedo, Eliana V.P. Silva, Valéria L. Carvalho, Sueli G. Rodrigues, Joaquim P. Nunes Neto, Hamilton A.O. Monteiro, Victor S. Peixoto, Jannifer O. Chiang, Márcio R.T. Nunes, Pedro F.C. Vasconcelos   +9 more
doaj   +1 more source

Structural Relationships to Efficacy for Prazole‐Derived Antivirals

Advanced Science, Volume 11, Issue 18, May 15, 2024.
Characterization of a family of covalent prazole derivative adducts with the Tsg101 UEV domain finds roles for bulk and flexibility in antiviral efficacy and cytotoxicity, while opening avenues for further development of prazole‐based antiviral therapeutics that target Tsg101.
David A. Nyenhuis, Susan Watanabe, Rebecca Bernstein, Rolf E. Swenson, Natarajan Raju, Venkata R. Sabbasani, Chandrasekhar Mushti, Duck‐Yeon Lee, Carol Carter, Nico Tjandra   +9 more
wiley   +1 more source

Unexpected arboviruses found in an epidemiological surveillance of acute tropical febrile syndrome in the department of Meta, Eastern Colombia

Journal of Infection and Public Health
Background: Nonspecific acute tropical febrile illnesses (NEATFI) are common in the Latin American tropics. Dengue, Chikungunya, Zika, Mayaro, and Usutu, among others, can coexist in the American tropics.
Liliana Sánchez-Lerma, Andres Rojas-Gulloso, Jorge Miranda, Vanesa Tique, Luz Helena Patiño, Derly Rodriguez, Verónica Contreras, Alberto Paniz-Mondolfi, Norma Pavas, Juan David Ramírez, Salim Mattar   +10 more
doaj   +1 more source