Results 11 to 20 of about 2,496 (195)
Calcium/Calmodulin-Dependent Protein Kinase II Inhibitors Mitigate High-Fat Diet-Induced Obesity in Mice. [PDF]
J ObesCalcium signaling contributes to obesity and its related disorders, such as diabetes. We herein investigated the effects of calcium/calmodulin‐dependent protein kinase II (CaMKII) inhibitors on diet‐induced obesity in mice. In mice fed a high‐fat diet (HFD), the administration of the CaMKII inhibitor KN‐93 and the glycolipid acremomannolipin A with the
Kawao N +7 more
europepmc +2 more sources
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Obesity in South and Southeast Asia—A new consensus on care and management
Obesity Reviews, Volume 24, Issue 2, February 2023., 2023 Summary Obesity is a chronic disease in which the abnormal or excessive accumulation of body fat leads to impaired health and increased risk of mortality and chronic health complications. Prevalence of obesity is rising rapidly in South and Southeast Asia, with potentially serious consequences for local economies, healthcare systems, and quality of ...
Kwang Wei Tham +15 more
wiley +1 more source
Long‐term weight loss maintenance with obesity pharmacotherapy: A retrospective cohort study
Obesity Science &Practice, Volume 8, Issue 3, Page 320-327, June 2022., 2022 Abstract Objective To determine the association of anti‐obesity medications (AOMs) with weight loss maintenance over 2 years. Methods This is a retrospective observational cohort study of adults treated for obesity between 1 April 2014 and 1 April 2016 at a tertiary academic weight management center and who completed 2 years of follow‐up.
Beverly G. Tchang +4 more
wiley +1 more source
The incretin/glucagon system as a target for pharmacotherapy of obesity
Obesity Reviews, Volume 23, Issue 2, February 2022., 2022 Summary Obesity is a chronic, multifactorial, relapsing disease. Despite multicomponent lifestyle interventions, including pharmacotherapy, maintaining bodyweight loss is challenging for many people. The pathophysiology of obesity is complex, and currently approved pharmacotherapies only target a few of the many pathways involved; thus, single ...
Stefano Del Prato +3 more
wiley +1 more source
Oxytocin receptor activation does not mediate associative fear deficits in a Williams Syndrome model
Genes, Brain and Behavior, Volume 21, Issue 1, January 2022., 2022 Central administration of an oxytocin receptor antagonist does not rescue reduced contextual or cued fear responses in CD mice. Abstract Williams Syndrome results in distinct behavioral phenotypes, which include learning deficits, anxiety, increased phobias and hypersociability.
Kayla R. Nygaard +6 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022 The incidence of obesity and over bodyweight is emerging as a major health concern. Obesity is a complex metabolic disease with multiple pathophysiological clinical conditions as comorbidities are associated with obesity such as diabetes, hypertension, cardiovascular disorders, sleep apnea, osteoarthritis, some cancers, and inflammation‐based clinical ...
Vikram Kumar +6 more
wiley +1 more source
Obesity Reviews, Volume 22, Issue 11, November 2021., 2021 Summary Anti‐obesity medications (AOMs) are efficacious and well tolerated in randomized controlled trials, but findings may not be generalizable to routine clinical practice. This systematic literature review aimed to identify real‐world (RW) evidence for AOMs to treat adults ( ≥ 18 years) with obesity or overweight (BMI ≥ 27 kg/m2).
Nadia N. Ahmad +4 more
wiley +1 more source
Avaliação do consumo de anorexígenos em diferentes farmácias de Salvador
Jornal de Assistência Farmacêutica e Farmacoeconomia, 2023 Introdução: Os anorexígenos são medicamentos muito populares no Brasil e estão entre os mais consumidos. Seu consumo, no entanto, é cercado de polêmicas e usos indevidos ou exagerados que remetem a uma série de consequências para a saúde pública.
Anderson Silva de Oliveira +2 more
doaj +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters
British Journal of Pharmacology, Volume 178, Issue S1, Page S412-S513, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +24 more
wiley +1 more source