Cell Reports, 2021 Summary: The Melanocortin-4 Receptor (MC4R) plays a pivotal role in energy homeostasis. We used human MC4R mutations associated with an increased or decreased risk of obesity to dissect mechanisms that regulate MC4R function.
Bas Brouwers +17 more
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Anti-melanocortin-4 receptor autoantibodies in obesity [PDF]
, 2009 Background: The melanocortin-4 receptor (MC4R) is part of an important pathway regulating energy balance. Here we report the existence of autoantibodies (autoAbs) against the MC4R in sera of obese patients.
Bekel, A. +9 more
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Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective [PDF]
, 2019 The melanocortin-4 receptor (MC4R) can be endogenously activated by binding of melanocyte-stimulating hormones (MSH), which mediates anorexigenic effects. In contrast, the agouti-related peptide (AgRP) acts as an endogenous inverse agonist and suppresses
Biebermann, Heike +10 more
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The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]
, 2015 The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M. +10 more
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The melanocortin receptors and their accessory proteins. [PDF]
, 2013 The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Chan, LF +3 more
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A nutrigenetic approach to investigate the relationship between metabolic traits and vitamin D status in an Asian Indian population [PDF]
, 2020 Studies in Asian Indians have examined the association of metabolic traits with vitamin D status. However, findings have been quite inconsistent. Hence, we aimed to explore the relationship between metabolic traits and 25-hydroxyvitamin D [25(OH)D ...
Alathari, Buthaina E. +11 more
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Current Mechanistic and Pharmacodynamic Understanding of Melanocortin-4 Receptor Activation
Molecules, 2019 In this work we summarize our understanding of melanocortin 4 receptor (MC4R) pathway activation, aiming to define a safe and effective therapeutic targeting strategy for the MC4R.
Shubh Sharma +7 more
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The Relation between Childhood Obesity and MC4R Gene and Near MC4R Polymorphisms
Gazi Medical Journal, 2020 Childhood obesity, especially in the developed countries including all over the world has an increasing prevalence. Regarding the major impact on public health perspective, childhood obesity should be monitored closely. Many researchers reported MC4R gene and near MC4R region polymorphisms to predispose monogenic obesity both in children and adults. In
Erkal, Ozgur +4 more
openaire +2 more sources
Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]
, 2016 Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta +12 more
core +4 more sources
A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. [PDF]
PLoS ONE, 2012 Heterozygous mutations in the melanocortin-4 receptor (MC4R) gene represent the most frequent cause of monogenic obesity in humans. MC4R mutation analysis in a cohort of 77 children with morbid obesity identified previously unreported heterozygous ...
Susana Granell +6 more
doaj +1 more source