Results 81 to 90 of about 11,016 (204)

SUN-602 Weight Loss After Glucagon-Like Peptide-1 Receptor Agonist Treatment in Childhood Obesity with Diabetes and Cirrhosis Associated with a Homozygous MC4R Mutation [PDF]

, 2020
Philippe Klee, Mirjam Dirlewanger, Valérie A. McLin, Maria Teresa Carminho‐Rodrigues, Valérie Schwitzgebel   +4 more
openalex   +1 more source

High-resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

eLife
Deep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment.
Conor J Howard, Nathan S Abell, Beatriz A Osuna, Eric M Jones, Leon Y Chan, Henry Chan, Dean R Artis, Jonathan B Asfaha, Joshua S Bloom, Aaron R Cooper, Andrew Liao, Eden Mahdavi, Nabil Mohammed, Alan L Su, Giselle A Uribe, Sriram Kosuri, Diane E Dickel, Nathan B Lubock   +17 more
doaj   +1 more source

Mutational analysis of the melanocortin-4 receptor (MC4R) gene in children with premature pubarche and adolescent girls with hyperandrogenism [PDF]

, 2004
M.B. Roldán Martín, Carlie White, Candace M. Kammerer, Selma F. Witchel   +3 more
openalex   +1 more source

Distinct Calcium Signaling for Wildtype, Loss-of-Function and Gain-of-Function Human MC4R Variants [PDF]

, 2021
Shree S Kumar, Kathleen G. Mountjoy
openalex   +1 more source

SNPs detection in 5’-UTR region of the MC4R gene in Garut sheep

, 2021
A P Z N L Sari, Ichda Rufaida Athifa, Panjono, Rahmat Hidayat, A Barli, Dyah Maharani   +5 more
openalex   +1 more source

Association between genetic variants in ANGPTL4 (T266M) and MC4R genes predisposing to obesity

, 2022
Zainab Adel Abbas
openalex   +2 more sources

A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice

The Journal of Clinical Investigation
Melanocortin 4 receptor (MC4R) mutations are the most common cause of human monogenic obesity and are associated with hyperphagia and increased linear growth.
Peter J. Metzger, Aileen Zhang, Bradley A. Carlson, Hui Sun, Zhenzhong Cui, Yongqi Li, Marshal T. Jahnke, Daniel R. Layton, Meenakshi B. Gupta, Naili Liu, Evi Kostenis, Oksana Gavrilova, Min Chen, Lee S. Weinstein   +13 more
doaj   +1 more source

Melanocortin 4 receptor-expressing neurons in the lateral stripe of the striatum regulate affect and motor control

iScience
Summary: The dopaminergic system is crucial for affect regulation. Melanocortin 4 receptors (MC4R) in the ventral striatum have been shown to be necessary for establishing aversive states.
Johan Sköld, Gisela Paola Lazzarino, Myra Nett, Joost Wiskerke, David Engblom   +4 more
doaj   +1 more source

Association study between near-MC4R variants and obesity-related variables in Portuguese young adults [PDF]

, 2016
Licínio Manco, Magdalena Muc, Cristina Padez   +2 more
openalex   +1 more source

MC4R: A Genetic Key to Metabolic and Cardiovascular Disorders

Biomedical Sciences and Clinical Medicine
The melanocortin-4 receptor (MC4R) is a critical regulator of energy homeo-stasis, lipid metabolism, and cardiovascular risk factors. First cloned in 1993, MC4R’s role in appetite regulation was confirmed through animal studies, and its genetic ...
Joby P Jose, Sumanth Kumar B, N Muninathan, K Ramesh Kumar, Vishnu M G, Sebastian J Pengiparambil, Sinha Mathew, Harisree P H, Roshma Retnakaran, Pinchulatha K, Thahira A, Swathi T, Dinesh Roy D   +12 more
doaj   +1 more source