Results 101 to 110 of about 5,865,115 (353)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Роль ТВР-В як посередника у дії доксорубіцину на клітини карциноми молочної залози ліній MCF-7(WT) та MCF(DOX/R) [PDF]

, 2015
Метою роботи було дослідити вплив протипухлинного препарату доксорубіцину на експресію мРНК ТФР-β та його рецепторів у клітинах карциноми молочної залози, чутливих (MCF-7(wt)) та резистентних (MCF-7(DOX/R)) до дії ...
Chorna, Inna Valentynivna, Репетун, А.В., Черная, Инна Валентиновна, Чорна, Інна Валентинівна, Шкандала, А.Ю.   +4 more
core  

Arsenic trioxide downregulates cancer procoagulant activity in MCF-7 and WM-115 cell lines in vitro [PDF]

, 2015
© 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing ...
Gizelska, Katarzyna, Hoffman, Ewelina A, Mielicki, Wojciech, Mirowski, Marek   +3 more
core   +2 more sources

A Critical Dose of Doxorubicin Is Required to Alter the Gene Expression Profiles in MCF-7 Cells Acquiring Multidrug Resistance

PLoS ONE, 2015
Cellular mechanisms of multidrug resistance (MDR) are related to ABC transporters, apoptosis, antioxidation, drug metabolism, DNA repair and cell proliferation. It remains unclear whether the process of resistance development is programmable. We aimed to
S. Tsou, Tzer-ming Chen, Hui-ting Hsiao, Yen-Hui Chen   +3 more
semanticscholar   +1 more source

Advancements in Understanding the Physicochemical Properties of Reticular Materials: An In Situ and Operando Spectroscopic Perspective

Advanced Materials, EarlyView.
This review explores how in situ and operando spectroscopic techniques reveal the real‐time behavior of reticular materials, including MOFs and COFs. These methods track material formation and functionalization, structural changes, defect formation, dynamic responses to external triggers, and catalytic processes.
Bettina Baumgartner, Anna Wach, Xinwei Ye, Evelyn Ploetz, Bert M. Weckhuysen   +4 more
wiley   +1 more source

Human Umbilical Cord Mesenchymal Stem Cells Promote Breast Cancer Metastasis by Interleukin-8- and Interleukin-6-Dependent Induction of CD44/CD24 Cells

Cell Transplantation, 2015
Although emerging evidence links mesenchymal stem cells (MSCs) with cancer metastasis, the underlying mechanisms are poorly understood. In the present study, we found that human umbilical cord-derived MSCs (UC-MSCs) promoted MCF-7 cell migration in vitro
Fengxia Ma, Dandan Chen, Fang Chen, Ying Chi, Zhibo Han, Xiaoming Feng, Xue Li, Zhongchao Han   +7 more
doaj   +1 more source

Reversal Effect of Apatinib on P-gp-mediated Multidrug Resistance of Human Breast Cancer and Its Mechanisms

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the reversal effect of apatinib on the multidrug resistance of human breast cancer and the underlying mechanisms. Methods MCF-7 and MCF-7/ADR cells were treated with different concentrations of apatinib for 48h.
ZHANG Shengcun, MA Min, XU Lili
doaj   +1 more source

Construction of single-chain variable fragment antibodies against MCF-7 breast cancer cells. [PDF]

, 2013
A phage display library of single chain variable fragment (scFv) against MCF-7 breast cancer cells was constructed from C3A8 hybridoma cells. RNA from the C3A8 was isolated, cDNA was constructed, and variable heavy and light immunoglobulin chain gene ...
Ahmad, Zuhaida Asra, Ali, Abdul Manaf, Hamid, Muhajir, Mohamed Alitheen, Noorjahan Banu, Noor, A. M., Subramani, Tamilselvan, Yeap, Swee Keong   +6 more
core   +1 more source

Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line

Cancer Cell International, 2015
Breast cancer is the most prevalent malignancies among the women that have a high mortality. Previous studies demonstrated that hypericin, a bioactive component of Hypericum perforatum have a cytotoxic effect on the malignant cell lines. However, an anti-
S. A. Mirmalek, M. Azizi, Ehsan Jangholi, Soheila Yadollah-Damavandi, M. Javidi, Yekta Parsa, T. Parsa, Seyed Alireza Salimi-Tabatabaee, Hossein Ghasemzadeh kolagar, Reza Alizadeh-Navaei   +9 more
semanticscholar   +1 more source

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source