Results 121 to 130 of about 7,687,713 (299)

Transcriptomic Changes in Cisplatin-Resistant MCF-7 Cells

International Journal of Molecular Sciences
Breast cancer is a leading cause of cancer-related deaths among women. Cisplatin is used for treatment, but the development of resistance in cancer cells is a significant concern. This study aimed to investigate changes in the transcriptomes of cisplatin-resistant MCF7 cells.
Araceli Ruiz-Silvestre, Alfredo Garcia-Venzor, Gisela Ceballos-Cancino, José M. Sánchez-López, Karla Vazquez-Santillan, Gretel Mendoza-Almanza, Floria Lizarraga, Jorge Melendez-Zajgla, Vilma Maldonado   +8 more
openaire   +2 more sources

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cells [PDF]

, 2008
The influence of 2-methoxyestradiol (2ME) was investigated on cell growth, morphology and spindle formation in a tumorigenic (MCF-7) and non-tumorigenic (MCF-12A) epithelial breast cell line.
Lottering, Mona-Liza, Joubert, Annie M., Van Zijl, Catherina, Steffens, Francois E.   +3 more
core   +1 more source

Clustering analysis of mRNA expression profiles of MCF- 7 and MCF-7-MEK5 cells.

, 2013
Microarray results demonstrating MCF-7 (left column) and MCF-7-MEK5 (right column) cell lines have distinctive gene expression patterns, with samples of same cell lines clustered together. Trees on the left are gene clusters. Data represented as mean ± S.
Seung Yoon Nam (444015), Rongye Lai (444011), Yan Tang (195081), Barbara S. Beckman (444019), Matthew E. Burow (116354), Bin Shan (303309), Odile David (444017), Guandi Wang (444018), Steven Elliott (444014), Ashley M. Nitzchke (444013), Wei Xiong (58411), Kenneth P. Nephew (212536), Lyndsay V. Rhodes (116340), Bridgette Collins-Burow (444016), Virgilo A. Salvo (444012), James W. Antoon (444010), Elizabeth C. Martin (116333)   +16 more
core   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Near‐Infrared Triggered Rechargeable Singlet Oxygen Battery for Sustained Phototherapy: Fast Charging and Long‐Lasting Discharging

Advanced Science, EarlyView.
A near‐infrared‐triggered rechargeable singlet oxygen battery based on PBDP nanoparticles is developed. Upon 808 nm irradiation for 5 min, the system enables efficient singlet oxygen generation, reversible storage via cycloaddition, and sustained release for up to 1 h after light cessation.
Yuxin Ren, Ling Li, Xinyi Zhang, Meiqi Li, Junqing Wang, Mengpan Zhang, Jian Wang, Yanli Tang   +7 more
wiley   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Effects of the MCF-7 Exhausted Medium on hADSC Behaviour

International Journal of Molecular Sciences
Stem cells possess the ability to differentiate into different lineages and the ability to self-renew, thus representing an excellent tool for regenerative medicine. They can be isolated from different tissues, including the adipose tissue. Adipose tissue and human adipose-derived stem cells (hADSCs) are privileged candidates for regenerative medicine ...
Giuseppe Garroni, Sara Cruciani, Diletta Serra, Renzo Pala, Donatella Coradduzza, Maria Laura Cossu, Giorgio Carlo Ginesu, Carlo Ventura, Margherita Maioli   +8 more
openaire   +2 more sources