Results 131 to 140 of about 209,877 (306)

Comparative metabolomics of MCF-7 and MCF-7/TAMR identifies potential metabolic pathways in tamoxifen resistant breast cancer cells

American Journal of Translational Research
Breast cancer is the most common cancer and the leading cause of cancer-related death among women. An Estrogen Receptor (ER) antagonist called tamoxifen is used as an adjuvant therapy for ER-positive breast cancers. Approximately 40% of patients develop tamoxifen resistance (TAMR) while receiving treatment.
Alok, Mishra, Anubhav, Srivastava, Anshuman, Srivastava, Lokendra Kumar, Sharma, Anand Kumar, Mishra, Ashutosh, Shrivastava   +5 more
openaire   +2 more sources

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

M3-Muscarinic Receptor Activation of ERK and Cell Growth Requires Calcium/Calmodulin-dependent Protein Kinases in MCF-7 Cells

, 2008
The extracellular signal-regulated protein kinase (ERK) signaling pathway is found in diverse cells throughout the human body. ERK activation has been implicated in breast cancer cell growth and proliferation.
Abell, ellen, Schmitt, John M, Wagner, Andrea   +2 more
core  

Biodegradable Eri silk nanoparticles as a delivery vehicle for bovine lactoferrin against MDA-MB-231 and MCF-7 breast cancer cells

, 2015
This study used the Eri silk nanoparticles (NPs) for delivering apo-bovine lactoferrin (Apo-bLf) (~2% iron saturated) and Fe-bLf (100% iron saturated) in MDA-MB-231 and MCF-7 breast cancer cell lines.
Kanwar, Jagat R., Kanwar, Rupinder K., Patel, Yogesh S., Rajkhowa, Rangam, Roy, Kislay, Wang, Xungai   +5 more
core   +2 more sources

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

Effect of anticancer drugs on breast cancer cells sensitive and resistant to doxorubicin: expression of mRNA of TGF-β and its receptors [PDF]

, 2014
Мета. Порівняльний аналіз впливу протипухлинних препаратів (доксорубіцину, метотрексату та цисплатину) на експресію мРНК трансформуючого фактора росту β (ТФР-β) і його рецепторів у клітинах карциноми молочної залози людини лінії MCF-7, чутливих (wt) і ...
Chorna, Inna Valentynivna, Fedorenko, Oleksandr Viktorovich, Stoika, Rostislav Stepanovych, Стойка, Ростислав Степанович, Стойка, Ростислав Степанович, Федоренко, Александр Викторович, Федоренко, Олександр Вікторович, Черная, Инна Валентиновна, Чорна, Інна Валентинівна   +8 more
core  

Reduced‐Graphene Oxide Nanofiltration Membranes Intercalated by Conjugated Polyaromatics: Towards High Monovalent Salt Rejections

Advanced Science, EarlyView.
We demonstrate the fabrication of a series of reduced‐GO nanofiltration membranes containing intercalated polyaromatic conjugated molecules of different structural classes. These tuned‐nanochannel membranes perform “deep nanofiltration” with remarkably high monovalent salt rejections and near‐total divalent salt rejections in a large concentration ...
Muskan Sonker, Sankar Nair
wiley   +1 more source

Aplikasi Ko-kemoterapi Fraksi Etil Asetat Ekstrak Etanolik Daun Sambung Nyawa (Gynura Procumbens (Lour.) Merr.) Pada Sel Kanker Payudara Mcf-7 [PDF]

, 2009
Combination chemotherapy has been an interesting attention in recent years to cure cancer e.g. non-toxic or less toxic phytochemicals are being combined with chemo-therapeutic agents to sensitize cancer cell and to enhance the efficacy of chemothera ...
Jenie, R. I. (Riris), Meiyanto, E. (Edy)
core  

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Ekstrak Etanolik Herba Ciplukan (Physalis Angulata L.) Berefek Sitotoksik dan Menginduksi Apoptosis pada Sel Kanker Payudara Mcf-7 [PDF]

, 2011
Potensi sitotoksik Ciplukan (Physalis angulata L.) dan kemampuannya memacu apoptosis pada beberapa sel kanker perlu diteliti. Untuk itu, ekstrak etanol herba ciplukan (EC) diaplikasikan pada sel kanker payudara MCF-7 untuk mengetahui pengaruhnya terhadap
Armandari, I. (I), Fitria, M. (M), Ikawati, A. H. (A), Meiyanto, E. (E), Septhea, D. B. (D)   +4 more
core