Results 221 to 230 of about 114,577 (260)

Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations MCF-7/LCC1 and MCF-7/LCC2.

The Journal of steroid biochemistry and molecular biology, 1998
Androgen and estrogen metabolism was investigated in the hormone-dependent human breast cancer cell line MCF-7 and its two hormone-resistant sublines MCF-7/LCC1 and MCF-7/LCC2. Using the product isolation method, the activity of aromatase, 5alpha-reductase, 3alpha/beta-hydroxysteroid oxidoreductase and 17beta-hydroxysteroid oxidoreductase were ...
Jørgensen, L, Brünner, N, Spang-Thomsen, M, James, M R, Clarke, R, Dombernowsky, P, Svenstrup, B   +6 more
openaire   +2 more sources

SSCF-Hyperthermia Study in MCF-7 Spheroids – In Silicio

2021
Electromagnetic hyperthermia is an alternative treatment for cancer that has been carried out as an adjuvant to other cancer treatments such as chemotherapy and radiotherapy; this study shows the interaction between a cell culture of three dimensional MCF-7 spheroids (Michigan Cancer Foundation-7) inside a culture media and the electromagnetic ...
Hector Fabian Guarnizo Mendez, Angela Victoria Fonseca Benítez, Sandra Janneth Perdomo Lara, Sandra Johanna Morantes Medina, Cristian Andrés Triana Infante, Christian Camilo Cano Vásquez, Juan David Jaiquel Villamil, Sebastian Mesa Zafra   +7 more
openaire   +1 more source

Downregulation of SOK1 promotes the migration of MCF-7 cells

Biochemical and Biophysical Research Communications, 2011
SOK1 is a member of the germinal center kinase (GCK-III) subfamily but little is known about it, particularly with respect to its role in signal transduction pathways relative to tumor metastasis. By stably transfecting SOK1 siRNA into the MCF-7 breast cancer cell line we found that SOK1 promotes the migration of MCF-7 cells, as determined using wound ...
Xu-Dong, Chen, Chien-Yu, Cho
openaire   +2 more sources

Actions of insulin on MCF-7 cells that are synchronized with hydroxyurea

Molecular and Cellular Endocrinology, 1987
The role of insulin in stimulating metabolic processes in MCF-7 cells was studied in cells synchronized at the G1:S interphase of the cell cycle using hydroxyurea. Cells released from the hydroxyurea block progressed through one S-phase of the cell cycle when insulin was absent from the medium.
B E, Linebaugh, J A, Rillema
openaire   +2 more sources

Catecholestrogens are MCF-7 cell estrogen receptor agonists

The Journal of Steroid Biochemistry and Molecular Biology, 1993
Catecholestrogens are important metabolites of estradiol and estrone in the human. Considerable interest has focused on the catecholestrogens 2-hydroxy- and 4-hydroxyestradiol since they bind to the estrogen receptor with an affinity in the range of estradiol.
N, Schütze, G, Vollmer, I, Tiemann, M, Geiger, R, Knuppen   +4 more
openaire   +2 more sources

Optimization of estrogen growth response in MCF-7 cells

In Vitro Cellular & Developmental Biology - Animal, 1992
The factors involved in estradiol-17 beta induced growth stimulation of MCF-7 human breast cancer cells have been examined. Wild type MCF-7 cells (and clone E3) were shown to undergo slow growth in phenol-red-free medium containing specific calf sera. The E3 clone was used to document a mean 6-day growth stimulation of 3.35-fold (doubling time = 33 +/-
T E, Wiese, L G, Kral, K E, Dennis, W B, Butler, S C, Brooks   +4 more
openaire   +2 more sources

Radiation‐induced gene expression in MCF‐7 cells

International Journal of Radiation Biology, 2003
Detection of gene targets applicable to biological dosimetry and early detection of radiation-induced cell damage.MCF-7 human mammary carcinoma cells were exposed to 2 and 6 Gy X-rays. Expression of 1176 genes was traced with the Atlas Human 1.2 Array (Clontech).(1) Based on data reproducibility (about 98%), a new and improved analysis was employed. (2)
T, Stassen, M, Port, I, Nuyken, M, Abend
openaire   +2 more sources

Binding of progestagens to receptor proteins in MCF-7 cells

Journal of Steroid Biochemistry, 1983
With the aim of finding an explanation for the biological properties of progestagens currently used for contraceptive purposes, we have assessed their specificity for progesterone, androgen and oestrogen receptors in MCF-7 cells. The specificity of progestagens for the progesterone receptors in the cytosol fraction of MCF-7 cells was similar to that ...
E W, Bergink, F, van Meel, E W, Turpijn, J, van der Vies   +3 more
openaire   +2 more sources

Antiestrogenic Effects of LY 117018 in MCF-7 Cells

Endocrinology, 1983
LY 117018 is a nonsteroidal compound which has been shown to antagonize more effectively than tamoxifen the effects of estradiol in rats and mice. We have further defined the properties of this compound on cell growth and progesterone receptor (PR) induction and have compared inhibitory effects to relative binding affinity in a human breast cancer cell
S M, Scholl, K K, Huff, M E, Lippman
openaire   +2 more sources

Prolidase in human breast cancer MCF-7 cells

Cancer Letters, 1998
Prolidase (EC 3.4.13.9) is an ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of dipeptides containing C-terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline for collagen synthesis and cell growth.
J A, Palka, J M, Phang
openaire   +2 more sources