Results 261 to 270 of about 209,877 (306)

Invasive and metastatic properties of MCF‐7 cells and ras^H‐transfected MCF‐7 cell lines

International Journal of Cancer, 1992
AbstractIn vitro invasion and in vivo metastasis assays were performed with a panel of MCF‐7 cells transfected with isogenic constructs of mutated rasH genes. Both increased levels of rasH expression and rasH oncogene activation increased activity of derivative cell lines in in vitro invasion assays.
Gelmann, Edward P., Thompson, Erik W., Sommers, Connie L.   +2 more
openaire   +3 more sources

Radiation‐induced gene expression in MCF‐7 cells

International Journal of Radiation Biology, 2003
Detection of gene targets applicable to biological dosimetry and early detection of radiation-induced cell damage.MCF-7 human mammary carcinoma cells were exposed to 2 and 6 Gy X-rays. Expression of 1176 genes was traced with the Atlas Human 1.2 Array (Clontech).(1) Based on data reproducibility (about 98%), a new and improved analysis was employed. (2)
T, Stassen, M, Port, I, Nuyken, M, Abend
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Catecholestrogens are MCF-7 cell estrogen receptor agonists

The Journal of Steroid Biochemistry and Molecular Biology, 1993
Catecholestrogens are important metabolites of estradiol and estrone in the human. Considerable interest has focused on the catecholestrogens 2-hydroxy- and 4-hydroxyestradiol since they bind to the estrogen receptor with an affinity in the range of estradiol.
N, Schütze, G, Vollmer, I, Tiemann, M, Geiger, R, Knuppen   +4 more
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Prolidase in human breast cancer MCF-7 cells

Cancer Letters, 1998
Prolidase (EC 3.4.13.9) is an ubiquitously distributed imidodipeptidase that catalyzes the hydrolysis of dipeptides containing C-terminal proline or hydroxyproline. The enzyme plays an important role in the recycling of proline for collagen synthesis and cell growth.
J A, Palka, J M, Phang
openaire   +2 more sources

Phosphatidylcholine catabolism in the MCF-7 cell cycle

Biochemistry and Cell Biology, 2006
The catabolism of phosphatidylcholine (PtdCho) appears to play a key role in regulating the net accumulation of the lipid in the cell cycle. Current protocols for measuring the degradation of PtdCho at specific cell-cycle phases require prolonged periods of incubation with radiolabelled choline.
Weiyang, Lin, Gilbert, Arthur
openaire   +2 more sources

Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations MCF-7/LCC1 and MCF-7/LCC2.

The Journal of steroid biochemistry and molecular biology, 1998
Androgen and estrogen metabolism was investigated in the hormone-dependent human breast cancer cell line MCF-7 and its two hormone-resistant sublines MCF-7/LCC1 and MCF-7/LCC2. Using the product isolation method, the activity of aromatase, 5alpha-reductase, 3alpha/beta-hydroxysteroid oxidoreductase and 17beta-hydroxysteroid oxidoreductase were ...
Jørgensen, L, Brünner, N, Spang-Thomsen, M, James, M R, Clarke, R, Dombernowsky, P, Svenstrup, B   +6 more
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Effects of catechin, diclofenac and celecoxib on the proliferation of MCF-7 and LTED MCF-7 cells

Biomedicine & Preventive Nutrition, 2011
Abstract Breast cancer is common among women especially after menopause. Inflammation is now considered as a risk factor of cancer and cyclooxygenase-2 (COX-2) enzymes are highly expressed in many cancers. COX-2 is the inducible enzyme responsible for the synthesis of pro-inflammatory prostaglandins. There are evidences that COX inhibitors especially
N. Sookvanichsilp, K. Poemsantitham
openaire   +1 more source

Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells

Cancer Letters, 2005
Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 microM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109+/
Jean L, Lord, Ann, de Peyster, P J E, Quintana, Robert P, Metzger   +3 more
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MCF-7 cells lack the expression of Caspase-3

International Journal of Biological Macromolecules, 2023
With great interest, we read the paper "Chitosan nano-vehicles as biocompatible delivering tools for a new Ag(I)curcuminoid-Gboxin analog complex in cancer and inflammation therapy" published in the International Journal of Biological Macromolecules.
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Optimization of estrogen growth response in MCF-7 cells

In Vitro Cellular & Developmental Biology - Animal, 1992
The factors involved in estradiol-17 beta induced growth stimulation of MCF-7 human breast cancer cells have been examined. Wild type MCF-7 cells (and clone E3) were shown to undergo slow growth in phenol-red-free medium containing specific calf sera. The E3 clone was used to document a mean 6-day growth stimulation of 3.35-fold (doubling time = 33 +/-
T E, Wiese, L G, Kral, K E, Dennis, W B, Butler, S C, Brooks   +4 more
openaire   +2 more sources