Results 61 to 70 of about 124,045 (313)

MCF-7 Drug Resistant Cell Lines Switch Their Lipid Metabolism to Triple Negative Breast Cancer Signature [PDF]

, 2021
Jose Adriá-Cebrián, Sandra Guaita‐Esteruelas, Eric W.‐F. Lam, Marta Rodríguez-Balada, Jordi Capellades, Josefa Girona, Ana Maria Jimenez-Santamaria, Óscar Yanes, L. Masana, Josep Gumà   +9 more
openalex   +1 more source

Metallofullerenol Sc3N@C80(OH)18: A New Generation Radioprotector Protecting Human Erythrocytes Against Multiple Biochemical Damage Modes Upon Gamma Irradiation, Identifying It as a Scavenger of Short‐ and Long‐Lived Radicals

Advanced Healthcare Materials, EarlyView.
Metallofullerenol Sc3N@C80(OH)18 demonstrates strong radioprotective properties as a scavenger of both short‐ and long‐lived radicals. The study reveals protection of human erythrocytes from γ‐radiation–induced biochemical damage via post‐irradiation removal of primary and secondary reactive oxidants, supported by pulse radiolysis kinetics.
Jacek Grebowski, Maciej Studzian, Szymon Lekki‐Porebski, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko, Lukasz Pulaski   +6 more
wiley   +1 more source

ADİPONEKTİN’İN MCF-7 PROLİFERASYONU VE GİRELİN SEVİYESİ ÜZERİNE ETKİSİ

SDÜ Tıp Fakültesi Dergisi, 2022
Amaç Lokal ve sistemik faktörlerin, östrojen reseptörü pozitif meme kanseri riskinde artış olan postmenopozal obez kadınlarda meme kanseri hücrelerinin büyümesini yönlendirdiği gösterilmiştir. Postmenapozal dönemdeki obez kadınlarda, dolaşımdaki girelin hormonunun azaldığı, bazı tümör hücreleri tarafından üretildiği ve ayrıca tümör büyümesini ...
Uğur ŞAHİN, Melda ŞAHİN, Okan SANCER, Mustafa CALAPOĞLU, Nurgül ŞENOL   +4 more
openaire   +4 more sources

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

HUMAN PREADIPOCYTES INHIBIT PROLIFERATION OF MCF-7 BREAST CANCER CELL LINE [PDF]

Acta Medica Iranica, 2006
Cancer cell-stromal cell interaction plays a crucial role in the growth and invasion of tumor cells of various organs. It has been recently suggested that adipocytes and preadipocytes, two specific types of stromal cells, affect the biological behavior ...
I. Ragerdi Kashani, M. Barbarestani, F. Etesam, M. A. Shokrgozar, M. A. Abdolvahabi, P. Haddad, M. H. Noori Mokohi M. Hosseini   +6 more
doaj   +1 more source

Genetic variability in MCF-7 sublines: evidence of rapid genomic and RNA expression profile modifications

BMC Cancer, 2003
Background Both phenotypic and cytogenetic variability have been reported for clones of breast carcinoma cell lines but have not been comprehensively studied. Despite this, cell lines such as MCF-7 cells are extensively used as model systems.
Douzery Emmanuel JP, Birnbaum Daniel, Nguyen Catherine, Ursule Lisa, Orsetti Béatrice, Vendrell Julie, Chuchana Paul, Nugoli Mélanie, Cohen Pascale, Theillet Charles   +9 more
doaj   +1 more source

In vivo "MRI phenotyping" reveals changes in extracellular matrix transport and vascularization that mediate VEGF-driven increase in breast cancer metastasis. [PDF]

PLoS ONE, 2013
To gain new insights into the relationship between angiogenic factors in breast cancer and their effect on extracellular matrix (ECM) remodeling and metastasis, we characterized and validated the "metastatic signature" of human breast cancer cell lines ...
Arvind P Pathak, Stephen McNutt, Tariq Shah, Flonne Wildes, Venu Raman, Zaver M Bhujwalla   +5 more
doaj   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

S1 kills MCF-7/ADR cells more than MCF-7 cells: A protective mechanism of endoplasmic reticulum stress

Biomedicine & Pharmacotherapy, 2013
Drug resistance in chemotherapy for breast cancer is associated with high levels of P-glycoprotein (P-gp) as well as endoplasmic reticulum (ER) stress. In this paper, we aimed to evaluate the efficacy of a pan-BH3 mimetic S1 on drug-resistant MCF-7/ADR cells, and the roles of S1-induced ER stress in cell death.
Ting, Song, Furong, Liang, Zhichao, Zhang, Yubo, Liu, Hongkun, Sheng, Mingzhou, Xie   +5 more
openaire   +2 more sources