Results 51 to 60 of about 7,687,713 (299)

Effects of HIF-2α on Biological Function of Breast Cancer MCF-7 Cells

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the effect of HIF-2α on proliferation, invasion and colony forming abilities of breast cancer MCF-7 cells. Methods HIF-2α ORF/shRNA lentivirus vectors were transfected into MCF-7 cells respectively, and then we screened and ...
LIU Yuqiong, LI Na, HUANG Huifen, LI Huixiang   +3 more
doaj   +1 more source

Changes in the Sensitivity of MCF-7 and MCF-7/DX Breast Cancer Cells to Cytostatic in the Presence of Metformin

Molecules
Multidrug resistance is a serious problem in modern medicine and the reason for the failure of various therapies. A particularly important problem is the occurrence of multidrug resistance in cancer therapies which affects many cancer patients. Observations on the effect of metformin—a well-known hypoglycemic drug used in the treatment of type 2 ...
Justyna Płonka-Czerw, Luiza Żyrek, Małgorzata Latocha   +2 more
openaire   +4 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PRODH/POX-Dependent Celecoxib-Induced Apoptosis in MCF-7 Breast Cancer

Pharmaceuticals, 2021
Celecoxib (Cx), an inhibitor of cyclooxygenase 2, induces apoptosis of cancer cells. However, the mechanism of the chemopreventive effect remains not fully understood.
Magdalena Misiura, Ilona Ościłowska, Katarzyna Bielawska, Jerzy Pałka, Wojciech Miltyk   +4 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Overexpression of Cell Surface Cytokeratin 8 in Multidrug-Resistant MCF-7/MX Cells Enhances Cell Adhesion to the Extracellular Matrix

Neoplasia: An International Journal for Oncology Research, 2008
Accumulating evidence suggests that multiple complex mechanisms may be involved, simultaneously or complementarily, in the emergence and development of multidrug resistance (MDR) in various cancers. Cell adhesion-mediated MDR is one such mechanism.
Fang Liu, Zhong Chen, Jinhong Wang, Xiaofeng Shao, Ziyou Cui, Chunzheng Yang, Zhenping Zhu, Dongsheng Xiong   +7 more
doaj   +1 more source

Regulation of the Estrogen Receptor in MCF-7 Cells by Estradiol [PDF]

Molecular Endocrinology, 1988
The role of estradiol in the regulation of its cognate receptor in MCF-7 cells was investigated in this study. After treatment with 10(-9) M estradiol, the level of receptor protein was measured using an enzymeimmunoassay. By 6 h, the receptor protein declined by about 60% from a level of approximately 3.6 to 1.2 fmol/micrograms DNA.
M, Saceda, M E, Lippman, P, Chambon, R L, Lindsey, M, Ponglikitmongkol, M, Puente, M B, Martin   +6 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

MCF-7 cells were plated on low adhesion plates and left for 48h undisturbed until spheroids formed.

, 2016
hTERT-immortalised fibroblasts transduced with dsRED, were then added and cocultured for a further 48h. Cells were imaged using a dual purpose phase contrast and fluorescence microscope, which allowed visualisation of cell distribution, defined by the ...
Paul G. Morris (2833391), Marcus A. Moss (2833388), Grace C. Roberts (2833400), Deborah L. Holliday (2833403), Chelsea A. Palmer (2833394), Valerie Speirs (1679), Sarah L. Maltby (2833397), Emily Smart (2833406), Claire E. Nash (803490)   +8 more
core   +1 more source

Enhanced radiation response in radioresistant MCF-7 cells by targeting peroxiredoxin II [PDF]

, 2013
Anthony Joseph Gomez Diaz,1 Daniel Tamae,2 Yun Yen,3 JianJian Li,4 Tieli Wang1 1Department of Chemistry and Biochemistry, California State University at Dominguez Hills, Carson, CA, 2Center of Excellence in Environmental Toxicology, Department of ...
Yen, Yun, Diaz AJG, Tamae D, Wang T, Tamae, Daniel, Diaz, Anthony Joseph Gomez, Li JJ, Li, JianJian, Wang, Tieli, Yen Y   +9 more
core   +1 more source