Results 121 to 130 of about 106,995 (260)

Coupling Fluid Neutrals to Gyrokinetic Plasma Dynamics for Edge and SOL Turbulence Simulations

Contributions to Plasma Physics, EarlyView.
ABSTRACT Accurate modeling of turbulent transport in magnetic confinement fusion devices requires extending first‐principles gyrokinetic simulations from the core to the edge and scrape‐off layer (SOL), where additional physics—particularly plasma–neutrals interactions—must be included.
Sabine Ogier‐Collin, Philipp Ulbl, Wladimir Zholobenko, Frank Jenko   +3 more
wiley   +1 more source

Exploring the Anticancer Activity of Ruthenium(II)–Arene and Copper(I) Complexes Bearing N‐Heterocyclic Carbene Ligands Containing Azido, Pyridinium, and Ethisterone‐Derived Triazole Groups

European Journal of Inorganic Chemistry, EarlyView.
A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo, Chiara Tupini, Nicola Demitri, Ilaria Lampronti, Thomas Scattolin   +4 more
wiley   +1 more source

1‐(Acetylamino)thioxanthones and Derivatives: Synthesis From 1‐Halogenothioxanthones and Biological Properties

European Journal of Organic Chemistry, EarlyView.
The conversion of 1‐halogenothioxanthones into 1‐(acetylamino) derivatives and their NaH‐mediated cyclization have been optimized. This rapid method yields thiochromeno[4,3,2‐de]quinol‐2‐ones that exhibit promising in vitro anticancer activity. Institute and/or researcher Bluesky usernames: https://bsky.app/profile/iscr‐rennes.bsky.social.
Najet Ballagha, Frédéric Lassagne, William Erb, Isabelle Rouaud, Sophie Tomasi, Ziad Fajloun, Mona El Samarji, Mohamad Rima, Anamaria Mendonça Santos, Laurent Picot, Valérie Thiéry, Hédi M’Rabet, Florence Mongin   +12 more
wiley   +1 more source

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway. [PDF]

Oncol Rep
Feng H, He L, Umar T, Wang H, Gao Y, Chen G, Sun P, Yin L, Zhao W, Lu H, Deng G, Qiu C.   +11 more
europepmc   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

Comparative mechanical profiling of MCF-7 cells in 2D and 3D cultures via optical tweezers. [PDF]

Biomed Opt Express
Akbarpour Z, Malekmohammadi M, Taghizadeh-Tabarsi R, Akbari-Birgani S, Maleki M, Hajizadeh F.   +5 more
europepmc   +1 more source

Antimicrobial Sensitivity Profile and Resistance Gene Research in Escherichia coli Isolated From Water and Fish From Lagoa da Conceição, Florianópolis, SC, Brazil

Food Safety and Health, EarlyView.
This paper highlights a concerning scenario of environmental contamination by multidrug‐resistant bacteria, underscoring the need for integrated surveillance and control strategies to address antimicrobial resistance in aquatic environments within the context of One Health.
Francisco Lucas de Amorim Nascimento, Luan Amaral Alexandre, Cynthia Farias Manassi, Alice Cristina da Silva, Luísa Aimée Schmitt Lobe, Gustavo Rocha, Mateus Rocha Ribas, Victor Wolleck, Gabriele Caroline Gottschalk de Abreu, Alessandra Valéria Vortmann, Sheila Mello da Silveira, Rodrigo Barcellos Hoff, Jussara Kasuko Palmeiro, Silvani Verruck   +13 more
wiley   +1 more source

[Retracted] PTEN enhances G2/M arrest in etoposide‑treated MCF‑7 cells through activation of the ATM pathway. [PDF]

Oncol Rep
Zhang R, Zhu L, Zhang L, Xu A, Li Z, Xu Y, He P, Wu M, Wei F, Wang C.   +9 more
europepmc   +1 more source

In Vitro Raman Spectroscopic Characterization of Docetaxel‐Loaded Polymeric Nanoparticles

Helvetica Chimica Acta, EarlyView.
The chemotherapeutic drug docetaxel(DTX) is nanoformulated using Soluplus, Soluplus–TPGS, and Pluronic micelles and characterized by label‐free in vitro FT‐Raman spectroscopy. Distinct DTX Raman signatures confirm successful drug incorporation, while spectral decomposition reveals the superior performance of Soluplus–TPGS mixed micelles, paving the way
Sankar Jana, Emma Reig‐Martí, Constanze Schultz, Michael Schmitt, Tobias Meyer‐Zedler, S M Miftahul Islam, Iwan W. Schie, Ibane Abasolo, Miriam Royo, Juergen Popp   +9 more
wiley   +1 more source