Results 71 to 80 of about 106,995 (260)

The cellular uptake mechanism, intracellular transportation, and exocytosis of polyamidoamine dendrimers in multidrug-resistant breast cancer cells

International Journal of Nanomedicine, 2016
Jie Zhang,1 Dan Liu,1 Mengjun Zhang,1 Yuqi Sun,1,2 Xiaojun Zhang,1 Guannan Guan,1 Xiuli Zhao,1 Mingxi Qiao,1 Dawei Chen,1 Haiyang Hu1 1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 2Department of ...
Zhang J, Liu D, Zhang MJ, Sun YQ, Zhang XJ, Guan GN, Zhao XL, Qiao MX, Chen DW, Hu HY   +9 more
doaj  

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Effect of MMP-2 gene silencing on radiation-induced DNA damage in human normal dermal fibroblasts and breast cancer cells

Genes and Environment, 2019
Introduction Diagnostic and therapeutic ionizing radiation (IR) is one of the well known long term risk factors of breast cancer. Extremely lethal consequences of IR causes double-strand breaks, which are mainly responsible for genomic instability ...
Gugalavath Shailender, Seema Kumari, Patnala Kiranmayi, Rama Rao Malla   +3 more
doaj   +1 more source

Electroactive 3D Porous Graphene Foam Impedimetric Biosensor for Ultrasensitive Detection of MCF‐7‐Cells‐Derived Extracellular Vesicles in Human Serum

Advanced Materials Technologies, EarlyView.
A label‐free impedimetric biosensor based on electroactive 3D porous graphene foam enables ultrasensitive and selective detection of CD81 protein and MCF‐7 cell‐derived extracellular vesicles in human serum. Detection limits of 0.048 fg/mL for CD81 and ∼24 EVs/mL are achieved, demonstrating a robust platform for selective, label‐free, and ...
Michael Robert Furness, Ashish Kalkal, Tia Wardlaw, Jessica Valli, Suresh Chandra Baral, Pablo Lozano Sanchez, Marco Caffio, Sudhagar Pitchaimuthu, Olga Oikonomidou, Jason Webber, Nick R. Leslie, Anitha Devadoss   +11 more
wiley   +1 more source

Cadmium influences the 5-Fluorouracil cytotoxic effects on breast cancer cells

European Journal of Histochemistry, 2012
The aim of the research was to evaluate a heavy metal, Cadmium (Cd), which was used to produce alterations in human breast cancer cell line MCF-7.
Y. Asara, J. A. Marchal, P. Bandiera, V. Mazzarello, L. G. Delogu, M. A. Sotgiu, A. Montella, R. Madeddu   +7 more
doaj   +1 more source

Molecular profile and cell cycle in MCF-7 and MCF-7/Dox cells exposed to conventional and liposomal forms of doxorubicin.

Experimental oncology, 2009
To compare the molecular profile and cell cycle of sensitive and resistant to doxorubicin MCF-7 breast cancer cells upon exposition to conventional or liposome-encapsulated forms of doxorubicin.capital EM, Cyrilliccapital TE, Cyrilliccapital TE, Cyrillic-test, immunocytochemistry, flow cytometry.In sensitive MCF-7 cells the exposure to conventional but
Rusetskaya, N.V., Lukyanova, N.Yu., Chekhun, V.F.   +2 more
openaire   +2 more sources

Near‐Infrared‐Driven Metal–Organic Frameworks‐Based Nanorobots for Controlled Photothermal‐Chemical Therapy Synergistic Induction of Cancer Cell Death

Advanced Robotics Research, EarlyView.
To achieve efficient cancer cell death, a bowl‐shaped PDA@UiO‐66@DOX nanorobot drug‐delivery nanoplatform was developed. Near‐infrared irradiation not only drives the nanorobot to exhibit self‐thermophoretic motion and elevates temperature but also triggers Doxorubicin (DOX) release via hyperthermia, enhancing cancer cells uptake of DOX and thereby ...
Tong Lin, Jie Yang, Yongcheng Li, Yuepeng Cai, Xiaosong Zhou, Ting Chen, Renfeng Dong   +6 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Reversal Effect of Apatinib on P-gp-mediated Multidrug Resistance of Human Breast Cancer and Its Mechanisms

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the reversal effect of apatinib on the multidrug resistance of human breast cancer and the underlying mechanisms. Methods MCF-7 and MCF-7/ADR cells were treated with different concentrations of apatinib for 48h.
ZHANG Shengcun, MA Min, XU Lili
doaj   +1 more source