Results 41 to 50 of about 188,053 (286)
Bilateral microform cleft lip [PDF]
, 2006 Microform cleft lip (MCL), also called congenital healed cleft lip or cleft lip "frustré", is a rare congenital anomaly. MCL has been described as having the characteristic appearance of a typical cleft lip which has been corrected in utero. We present a
Attard Montalto, Simon +2 more
core
Advanced Healthcare Materials, EarlyView.Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez +6 more
wiley +1 more source
BiomedicinesBackground/Objectives: The multifactorial nature of immune-mediated inflammatory diseases (IMIDs) requires integrating pathophysiological understanding with subjective patient experiences.
Tessa S. Folkertsma +4 more
doaj +1 more source
Seeking a MCL-1 inhibitor [PDF]
Cell Death & Differentiation, 2013 The development of small molecule drugs that mimic the actions of BH3-only proteins is one of the major triumphs of many years of apoptosis research. They are built upon a platform of an understanding the mechanisms of action of BCL-2 family proteins, and particularly a structural appreciation of the interactions between BCL-2 family proteins.
G, Brumatti, P G, Ekert
openaire +2 more sources
Pulsed DC Sputter Deposition of Stable Turbostratic Boron Nitride Thin Films
Advanced Materials Interfaces, EarlyView.Boron nitride (BN) films are deposited by sputtering from a boron target. During deposition, a substrate bias voltage is applied between the plasma and the sample, which reduces excess boron in the film and enhances the crystallinity. This process prevents the formation of boric acid and ammonium borate hydrate.
Josef Schätz +9 more
wiley +1 more source
Shipin gongye ke-jiObjective: To study the protective effect and mechanism of ethanol extract from Paeonia suffruticosa seed on photoaging of HaCaT cells induced by UVB. Method: The anti-photoaging active ingredients in the ethanol extract of Paeonia suffruticosa seed were
Jiejun HAN +4 more
doaj +1 more source
Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation
Frontiers in Cell and Developmental Biology, 2020 As an important regulator of apoptosis, Mcl-1 protein, a member of the Bcl-2 family, represents an attractive target for cancer treatment. The recent development of novel small molecule compounds has allowed Mcl-1-inhibitory therapy to proceed to ...
Alena Y. Streletskaia +7 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundMantle cell lymphoma (MCL) with Epstein–Barr virus (EBV) infection is rarely reported. The objective of this study was to analyze the prevalence and clinicopathological features of MCL with EBV infection in the largest series thus far ...
Xiaoju Li +22 more
doaj +1 more source
Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]
, 2015 Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO +12 more
core +1 more source
Advanced Science, EarlyView.Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann +26 more
wiley +1 more source