Results 171 to 180 of about 3,352 (198)

Immunoglobulin Expressions Are Only Associated With MCPyV-positive Merkel Cell Carcinomas But Not With MCPyV-negative Ones

American Journal of Surgical Pathology, 2014
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer, often associated with Merkel cell polyomavirus (MCPyV). Recently, immunoglobulin (Ig) expression was reported in MCC, thereby suggesting that B cells might be their cellular ancestors.
Ichiro, Murakami, Katsuyoshi, Takata, Michiko, Matsushita, Daisuke, Nonaka, Takeshi, Iwasaki, Satoshi, Kuwamoto, Masako, Kato, Takashi, Mohri, Keiko, Nagata, Yukisato, Kitamura, Tadashi, Yoshino, Kazuhiko, Hayashi   +11 more
openaire   +2 more sources

In Vitro Replication Assay for Merkel Cell Polyomavirus (MCPyV)

Current Protocols in Microbiology, 2015
AbstractMerkel cell polyomavirus (MCPyV) genomes are clonally integrated in tumor cells of ∼95% of all Merkel cell carcinoma (MCC) cases. The virus is highly prevalent; however, where the virus persists and which cell types are permissive for MCPyV replication is still unknown. As a consequence, very little information is available about the life cycle
Friederike, Neumann, Manja, Czech-Sioli, Adam, Grundhoff, Nicole, Fischer   +3 more
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Merkel cell polyomavirus (MCPyV) in chronic lymphocytic leukemia/small lymphocytic lymphoma

Leukemia Research, 2011
Merkel cell polyomavirus (MCPyV) is a novel polyomavirus that shows a strong association with Merkel cell carcinoma (MCC). Recent studies have demonstrated MCPyV in some cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a malignancy with a similar demographic as MCC.
Carolin J, Teman, Sheryl R, Tripp, Sherrie L, Perkins, Eric J, Duncavage   +3 more
openaire   +2 more sources

KRT20-/SATB2+/MCPyV+ Sinonasal Merkel Cell Carcinoma: A Detailed Immunohistochemical and In Situ Hybridization Study

International Journal of Surgical Pathology
Merkel cell carcinoma (MCC) is an uncommon aggressive neoplasm, usually arising in sun-exposed skin of the head and neck. By immunohistochemistry, KRT20 and MCPyV positivity are found in about 90% and 80% of MCCs, respectively.
Gabriela Fonseca Rocha, H. Silveira, Herberth Campos Silva, F. Chahud, M. Brunaldi, Ana Terezinha Marques Mesquita, J. E. León   +6 more
semanticscholar   +1 more source

Genetic and molecular profiling in Merkel Cell Carcinoma: Focus on MCPyV oncoproteins and emerging diagnostic techniques.

Pathology, Research and Practice
Merkel Cell Carcinoma (MCC) is an uncommon yet highly malignant form of skin cancer, frequently linked to the Merkel cell polyomavirus (MCPyV). This review comprehensively covers data from year 2000 to 2024, employing keywords such as MCC, MCPyV ...
Harpreet Singh, Sourav Mohanto, Anil Kumar, A. Mishra, Arvind Kumar, Amrita Mishra, Mohammed Gulzar Ahmed, Mukesh Kr. Singh, Amrendra Pratap Yadav, Shivani Chopra, Hitesh Chopra   +10 more
semanticscholar   +1 more source

31 MCPyV and the immune system: Target and modulator

Oral Oncology, 2015
Merkel cell carcinoma (MCC) is a aggressive skin cancer associated with the Merkel cell polyomavirus (MCPyV). Presence of tumor-infiltrating lymphocytes and immune competence are strongly correlated with the course of the disease. MCPyV encoded proteins should be highly effective targets for cytotoxic immune responses as they are both foreign to the ...
J.C. Becker, S.R. Hadrup, D. Schrama, C. Ritter   +3 more
openaire   +1 more source

Prevalence of MCPyV in Merkel cell carcinoma and non‐MCC tumors

Journal of Cutaneous Pathology, 2009
Background: Merkel cell polyomavirus (MCPyV) is the likely causative agent of Merkel cell carcinoma (MCC). However, the prevalence of MCPyV in non‐MCC population and its possible role in the pathogenesis of other skin cancers are not known yet.Methods: A molecular pathology study was performed in 33 MCC samples and 33 age‐ and sex‐matched samples of ...
Christian, Andres, Benedetta, Belloni, Ursula, Puchta, Christian A, Sander, Michael J, Flaig   +4 more
openaire   +2 more sources

LT and SOX9 expression are associated with gene sets that distinguish Merkel cell polyomavirus (MCPyV)-positive and MCPyV-negative Merkel cell carcinoma

British Journal of Dermatology
Abstract Background Merkel cell carcinoma (MCC) is an aggressive malignant neuroendocrine tumour. There are two subsets of MCC, one related to Merkel cell polyomavirus (MCPyV) and the other to ultraviolet radiation (UVR).
Juan Torre-Castro, Marta Rodríguez, Ruth Alonso-Alonso, María Dolores Mendoza Cembranos, Jesús Frutos Díaz-Alejo, Marcos Rebollo-González, Jennifer Borregón, Laura Nájera Botello, Ignacio Mahillo-Fernández, Mathab Samimi, Thibault Kervarrec, Luis Requena, Miguel Ángel Piris   +12 more
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The new polyomavirus (MCPyV) does not affect the clinical course in MCCs

International Journal of Oral and Maxillofacial Surgery, 2010
Since 2008, a new polyomavirus (MCPyV) in Merkel cell carcinomas (MCC) has been described, but little is known about its impact on the clinical course. The purpose of this study was to determine the presence of MCPyV in a large sample and to correlate the results with the clinical course of the disease. 59 samples from 44 patients were analysed for the
J, Handschel, D, Müller, R A, Depprich, M A, Ommerborn, N R, Kübler, C, Naujoks, J, Reifenberger, K-L, Schäfer, S, Braunstein   +8 more
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Significant overexpression of the Merkel cell polyomavirus (MCPyV) large T antigen in Merkel cell carcinoma

Head & Neck, 2012
AbstractBackgroundThe purpose of this study was to determine the expression pattern of the Merkel cell polyomavirus (MCPyV) large T‐protein antigen in patients with Merkel cell carcinoma.MethodsA tissue microarray (TMA) containing 30 specimens was constructed and stained for the MCPyV large T protein.
Boban M, Erovic, Ayman, Al Habeeb, Luke, Harris, David P, Goldstein, Danny, Ghazarian, Jonathan C, Irish   +5 more
openaire   +2 more sources