Results 111 to 120 of about 3,368,671 (295)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Global Journal of Medicine and Public HealthSalmonella Typhi is a Gram-negative rod which causes enteric fever in humans. The introduction of antibiotics to treat typhoid has considerably improved its outcome, but rising multidrug-resistant (MDR) and extensively drug-resistant (XDR) cases due to ...
Mohd Arif +3 more
doaj +2 more sources
Emil Freireich, MD, Oral History Interview, August 13, 2001 [PDF]
, 2001 Major Topics Covered: The Department of Developmental Therapeutics; Building the culture of clinical research; training clinical researchers and physician-scientists ; MD Anderson presidents and the history and expansion of MD Anderson Institutional ...
Freireich, Emil J, MD, Brunet, Lesley W.
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Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Chapter 20: Contributions to MD Anderson
, 2013 Dr. Cox talks about his contributions to MD Anderson: he spurred clinical research and therefore contributed to the care of patients. Administratively he believes he helped foster collegiality across departments and division, making faculty comfortable ...
Cox, James D., MD +1 more
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Janet M. Bruner, MD, Oral History Interview, June 4, 2012 [PDF]
, 2012 Major Topics Covered: Personal and educational background Overviews of pathology and neuropathology, approach and practice in team settings Research: molecular genetics MD Anderson Neuropathology Laboratory: operations Developing the MD Anderson Tissue
Bruner, Janet M., MD +1 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Janet M. Bruner, MD, Oral History Interview, June 7, 2012 [PDF]
, 2012 Major Topics Covered: The Department of Pathology, subspecializing The Department of Hematopathology Women and leadership at MD Anderson Growth at MD Anderson, financial challenges, cultural changehttps://openworks.mdanderson.org/mchv_interviewsessions/
Bruner, Janet M., MD +1 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source