Results 211 to 220 of about 737,646 (322)

PKC-eta promotes breast cancer metastasis by regulating the Hippo-YAP signaling pathway. [PDF]

Signal Transduct Target Ther
Liju VB, Waidha K, Muraleedharan A, Jayaram DR, Haimov H, Jagadeeshan S, Manikandan DB, Shareb RA, Nurukurti L, Sklarz M, Gutkind JS, Allon I, Cohen O, Elkabets M, Livneh E.   +14 more
europepmc   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Strengthening health systems through NTD integration: Key insights from a multi-country webinar. [PDF]

PLoS Negl Trop Dis
Rozendaal N, Bassabi-Alladji MA, Bishaw T, Omondi W, Tolotra AF, Batchiri SA, Nshimiyimana L, Gnossike P, Jones C, Mubangizi A, Rebollo M.   +10 more
europepmc   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Differentiation of human iPSCs into dopaminergic neurons: comparative analysis of 2D and 3D protocols for disease modeling and pharmacology. [PDF]

Neurosci Appl
Marcotto GS, Bitraj J, Merlo Pich E, Collo G.   +3 more
europepmc   +1 more source

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, EarlyView.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Decyl caffeate inhibits the proliferation of human triple negative breast cancer cells. [PDF]

Biomedicine (Taipei)
Chao CY, Shyu WC, Lin CL, Chiang EI, Kuo YH, Tang FY.   +5 more
europepmc   +1 more source

MDA-9/syntenin is a key regulator of glioma pathogenesis.

Neuro-Oncology, 2014
T. Kegelman, Swadesh K. Das, Bin Hu, M. Bacolod, C. Fuller, M. E. Menezes, L. Emdad, S. Dasgupta, A. Baldwin, J. Bruce, P. Dent, M. Pellecchia, D. Sarkar, P. Fisher   +13 more
semanticscholar   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

The Cost of Annual and More Frequent Than Annual Mass Drug Administration for Trachoma in Two Districts in Amhara, Ethiopia. [PDF]

Am J Trop Med Hyg
Jesudason T, Ahmed S, Turner HC, Sata E, Shiferaw A, Demmelash T, Abebe A, Sanon A, Callahan EK, Jensen KA, Nash SD.   +10 more
europepmc   +1 more source