Results 51 to 60 of about 541,611 (331)

MDA—Lymphatic Filariasis

Tropical Medicine and Health, 2014
Lymphatic filariasis is one of the neglected tropical diseases. It is estimated that 120 million people are currently infected in 73 countries where filariasis is endemic. Lymphatic filariasis is a leading cause of chronic disability worldwide, including of 15 million people who have lymphoedema (elephantiasis) and 25 million men who have hydrocoele.
openaire   +3 more sources

Determinants of MDA impact and designing MDAs towards malaria elimination

eLife, 2020
Malaria remains at the forefront of scientific research and global political and funding agendas. Malaria models have consistently oversimplified how mass interventions are implemented. Here, we present an individual based, spatially explicit model of P.
Gao, B, Saralamba, S, Lubell, Y, White, LJ, Dondorp, AM, Aguas, R   +5 more
openaire   +5 more sources

Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells. [PDF]

, 2017
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed \u27small RNA zipper\u27.
Chen, Yi-Han, Deng, Shengqiong, Fan, Huiming, Li, Wenshu, Liu, Cuicui, Liu, Zhongmin, Lu, Ying, Lü, Jinhui, Meng, Lingyu, Pestell, Richard G., Qiao, Jing, Wang, Guangxue, Yu, Zuoren, Zhang, Chuyi, Zhang, Yuzhen, Zhao, Qian, Zhen, Lixiao   +16 more
core   +2 more sources

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Extremes of Aggregated Dirichlet Risks [PDF]

, 2014
The class of Dirichlet random vectors is central in numerous probabilistic and statistical applications. The main result of this paper derives the exact tail asymptotics of the aggregated risk of powers of Dirichlet random vectors when the radial ...
Hashorva, Enkelejd
core   +3 more sources

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Extension of Petri Nets by Aspects to Apply the Model Driven Architecture Approach [PDF]

, 2005
Within MDA models are usually created in the UML. However, one may prefer to\ud use different notations such as Petri-nets, for example, for modelling concurrency\ud and synchronization properties of systems. This paper claims that techniques that\ud are
Aksit, M., Roubtsova, E.E.
core   +1 more source

Synthesis of Curcumin Derivatives and Analysis of Their Antitumor Effects in Triple Negative Breast Cancer (TNBC) Cell Lines [PDF]

, 2019
We analyzed antitumor effects of a series of curcumin analogues. Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original ...
Barattucci A, Bonaccorsi PM, Labbozzetta M, Notarbartolo M, Poma P, Salerno TMG   +5 more
core   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Caring for children with spinal muscular atrophy in Greece: parents' and caregivers' experience with the healthcare system

Frontiers in Health Services
IntroductionSpinal muscular atrophy (SMA) is a rare disease characterized by challenges in its management both for patients and parents/caregivers. In Greece, these challenges are exacerbated by the lack of an integrated SMA patient pathway.
Kyriakos Souliotis, Kyriakos Souliotis, Christina Golna, Chara Tzavara, Christiana Vasileiadi, Pavlos Golnas, Aikaterini Ntokou, Kornilia Binou, Antigone Karras   +8 more
doaj   +1 more source