Results 61 to 70 of about 458,494 (300)

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Caring for children with spinal muscular atrophy in Greece: parents' and caregivers' experience with the healthcare system

Frontiers in Health Services
IntroductionSpinal muscular atrophy (SMA) is a rare disease characterized by challenges in its management both for patients and parents/caregivers. In Greece, these challenges are exacerbated by the lack of an integrated SMA patient pathway.
Kyriakos Souliotis, Kyriakos Souliotis, Christina Golna, Chara Tzavara, Christiana Vasileiadi, Pavlos Golnas, Aikaterini Ntokou, Kornilia Binou, Antigone Karras   +8 more
doaj   +1 more source

Hypoxia regulates stemness of breast cancer MDA-MB-231 cells

Medical Oncology, 2016
Human breast cancers include cancer stem cell populations as well as non-tumorigenic cancer cells. Breast cancer stem cells possess self-renewal capability and thus are the root cause of recurrence and metastasis of malignant tumors.
Jing Xie, Yong Xiao, Xiao-yan Zhu, Z. Ning, Haifang Xu, Huimin Wu   +5 more
semanticscholar   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

Arhiv za Higijenu Rada i Toksikologiju, 2020
Most Pb and Cd neurotoxicity studies investigate exposure to either of the toxic metals alone, while data on co-exposure are scarce. The aim of our study was to fill that gap by investigating acute combined effects of Pb and Cd on redox and essential ...
Javorac Dragana, Đorđević Aleksandra Buha, Anđelković Milena, Tatović Simona, Baralić Katarina, Antonijević Evica, Kotur-Stevuljević Jelena, Đukić-Ćosić Danijela, Antonijević Biljana, Bulat Zorica   +9 more
doaj   +1 more source

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Changes in lipid peroxidation, glutathione and fertility in tuj sheep after combined administration of vitamin a and e and passive immunization with testosterone antibodies [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
This study investigated the effect of testosterone antibodies and a combination of vitamin A and E on reproductive performance and lipid peroxidation in Tuj sheep during the oestrus period.
KAMİLOĞLU NN, KAÇAR C, GÜVEN A, YILDIZ B, KURU M, KAYA S, EROĞLU HA, KOÇ E   +7 more
doaj   +1 more source

Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells

PLoS ONE, 2015
Pyruvate carboxylase (PC) is an anaplerotic enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, which is crucial for replenishing tricarboxylic acid cycle intermediates when they are used for biosynthetic purposes.
Phatchariya Phannasil, C. Thuwajit, M. Warnnissorn, J. Wallace, M. MacDonald, S. Jitrapakdee   +5 more
semanticscholar   +1 more source

Associations of lifestyle‐related factors and psoriatic arthritis disease activity: the Dutch south west psoriatic arthritis study

Arthritis Care &Research, Accepted Article.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients newly diagnosed with PsA, between 2013 and 2023. A composite lifestyle risk score (range 0 to 5) was calculated using five lifestyle‐
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Anti-angiogenesis therapy and gap junction inhibition reduce MDA-MB-231 breast cancer cell invasion and metastasis in vitro and in vivo

Scientific Reports, 2015
Cancer cells secrete VEGF, which plays a key role in their growth, invasion, extravasation and metastasis. Direct cancer cell-endothelial cell interaction, mediated by gap junctions, is of critical importance in the extravasation process.
K. Zibara, Zahraa Awada, Leila Dib, Jamal El-Saghir, Sara Al-Ghadban, A. Ibrik, Nabil El-zein, M. El-Sabban   +7 more
semanticscholar   +1 more source