Results 51 to 60 of about 384,184 (313)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Kadar Malondialdehyde (MDA) pada Pasien Kusta Reaksi dan Tanpa Reaksi [PDF]
, 2017 Rekasi kusta merupakan suatu episode akut di dalam perjalanan klinis penyakit kusta. Data dari beberapa penelitian menyebutkan terjadinya peningkatan kadar oksidan pada pasien kusta reaksi.
Indropo Agusni +2 more
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MDA-MB-231 +LaNt α31-eGFP invasion into Matrigel.
, 2022 MDA-MB-231 cells transduced with LaNt α31-eGFP were plated onto the outside of a transwell membrane. 10 ng mL-1 epidermal growth factor was used to stimulate invasion through the membrane and into Matrigel.
Tobias Zech (47625) +3 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Role of Pre-Sowing Gamma-Irradiation of Seeds in the Salt-Resistance of Phaseolus vulgaris L. [PDF]
Journal of Stress Physiology & Biochemistry, 2020 Studies of the effect of low-dose γ-radiation on the resistance of plants to abiotic stresses have recently attracted great attention of researchers due to the constant environmental degradation. In separate examples, it was shown that γ-radiation in low
E.S. Jafarov +4 more
doaj
Journal of Family Medicine and Primary Care, 2023 Background: Despite annual rounds of mass drug administration (MDA) being carried out every year since 2004 to break the transmission of lymphatic filariasis, India has not achieved elimination status in many areas of country. This study was conducted to
Dhananjay Kumar +4 more
doaj +1 more source
MDA-MB-231_siGENOME_GEFGGAP screen (Data Record 3).xlsx
, 2017 Raw data for the siGENOME RhoGEF and RhoGAP RNAi screen on MDA-MB-231 ...
Chris Bakal (192137) +5 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Figure1: C1-0d-MDA-MB-231GFPcells.zip
, 2016 The collective migration of MDA-MB-231 cells in a DIGME ...
Bo Sun (3132984)
core +1 more source