Results 61 to 70 of about 1,892 (112)

Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer

Cancer Medicine
Purpose Small cell lung cancer (SCLC) is a highly aggressive disease associated with poor patient survival rates. The addition of an anti‐programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis.
Shotaro Ito, Jun Sakakibara‐Konishi, Mineyoshi Sato, Tetsuaki Shoji, Megumi Furuta, Hirofumi Takahashi, Kosuke Tsuji, Daisuke Morinaga, Masahiro Kashima, Hidenori Kitai, Junko Kikuchi, Eiki Kikuchi, Kanako C. Hatanaka, Yutaka Hatanaka, Kyoko Hida, Takuro Noguchi, Satoshi Konno   +16 more
doaj   +1 more source

PRISM‐xQTL: Pleiotropic Relationships Integrated with System‐level Multiomic QTL analysis for causal genes and molecular mediators in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Most Alzheimer's disease (AD) risk variants identified by genome‐wide association studies (GWAS) reside in noncoding regions, complicating causal interpretation. METHODS We developed PRISM‐xQTL (Pleiotropic Relationships Integrated with System‐level Multiomic QTL), integrating pleiotropy, co‐localization, Mendelian randomization ...
Nitesh Enduru, Zhongming Zhao
wiley   +1 more source

The Long Noncoding RNA ZFAS1 Potentiates the Development of Hepatocellular Carcinoma via the microRNA-624/MDK/ERK/JNK/P38 Signaling Pathway

OncoTargets and Therapy, 2020
Background A long noncoding RNA (lncRNA), ZNFX1 antisense RNA 1 (ZFAS1), was increased in multiple cancers, including hepatocellular carcinoma (HCC), resulting in malignancy development and progression.
Rui Duan, Cai-yan Li, Fan Wang, F. Han, Ling Zhu   +4 more
semanticscholar   +1 more source

Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition

Communications Biology
Numerous myofibroblasts are arisen from endothelial cells (ECs) through endothelial to mesenchymal transition (EndMT) triggered by TGF-β. However, the mechanism of ECs transforms to a different subtype, or whether there exists an intermediate state of ...
Cuidi Xu, Juntao Chen, Lifei Liang, Siyue Chen, Xinhao Niu, Ruirui Sang, Cheng Yang, Ruiming Rong   +7 more
doaj   +1 more source

Integrative single‐cell analysis uncovers distinct tumour microenvironment ecotypes and immune evasion across skin cancers

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical highlights Tumour subpopulations with high malignancy show reduced interferon signalling and reduced MHC‐I expression. Tumour‐associated macrophages (TAMs) differentiate into two opposing states: SPP1+ TAMs and CXCL9+ TAMs. Among immune ecotypes, T‐cell‐enriched ecotypes are linked with high MHC‐I expression in tumour cells while desert ...
Lingjuan Huang, Huihui Hou, Xiyuan Zhang, Liang Dong, Wensheng Shi, Mason Liu, Jie Sun, Anil Prakash, Haoqiu Song, Shiyao Pei, Xin Li, Xiang Chen, Shenglin Mei, Mingzhu Yin   +13 more
wiley   +1 more source

BAG2, MAD2L1, and MDK are cancer-driver genes and candidate targets for novel therapies in malignant pleural mesothelioma

Cancer Gene Therapy
Malignant pleural mesothelioma (MPM) is an aggressive cancer with a poor prognosis and the identification of novel druggable targets is urgently needed.
Luisa Bisceglia, Federica Morani, Lara Guerrieri, E. Santoni-Rugiu, Pınar Çakılkaya, Cristian Scatena, R. Scarpitta, L. Engelholm, Niels Behrendt, F. Gemignani, Stefano Landi   +10 more
semanticscholar   +1 more source

The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer

Nature Communications
Younger premenopausal women are more prone to developing ovarian metastases (OM) of gastric cancer (GC) than metastases of other organs; however, the molecular mechanisms remain unclear. Here we perform single-cell RNA sequencing on 45 tumor samples from
Simeng Hu, Can Hu, Jingli Xu, Pengfei Yu, Li Yuan, Ziyu Li, Haohong Liang, Yanqiang Zhang, Jiahui Chen, Qing Wei, Shengjie Zhang, Litao Yang, Dan Su, Yian Du, Zhiyuan Xu, Fan Bai, Xiangdong Cheng   +16 more
doaj   +1 more source

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer

Journal of Experimental & Clinical Cancer Research, 2010
The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare the performance of MDK with that of anterior ...
Edgell Tracey A, Rice Gregory E, Autelitano Dominic J   +2 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression

Genes and Diseases
Growth factors are bioactive molecules that play crucial roles in regulating growth, development, and disease processes, both locally and systemically.
Xieyidai Ruze, Yutong Hu, Xiongyi Wang, Houfu Lai, Ruizhi Zhang, Sheng Pan, Jiajun Zhang, Yike Wang, Simin Yun, Ying Xu, Junjie Li, Youjia Xu   +11 more
doaj   +1 more source