Results 61 to 70 of about 6,785 (193)

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Intraoperative Variations of Cystic Artery and Duct in Laparoscopic Cholecystectomy: A Systematic Review With Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Laparoscopic cholecystectomy (LC) is the gold‐standard treatment for benign gallbladder disease but carries a higher risk of bile duct injury than the open approach, largely due to misidentification of critical hepatobiliary structures.
George Triantafyllou, Daniel Gondorf, Dimitrios K. Manatakis, Orestis Lyros, Panagis M. Lykoudis, Spyridon Christodoulou, Nikolaos Arkadopoulos, Maria Piagkou   +7 more
wiley   +1 more source

Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials

Cell Proliferation, EarlyView.
The hfPSC‐LCs could be established from naïve hESCs, conventional hESCs, hiPSCs, and human blastocysts. The hfPSC‐LCs hold robust capacity for three germ layers, hPGCLCs, and hALPCs. ABSTRACT Human embryos undergo pivotal morphogenetic remodelling shortly after implantation. The understanding of this crucial stage is severely impeded by the scarcity of
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei, Jianqiao Liu, Lei Li   +11 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Journal of Experimental & Clinical Cancer Research, 2018
Background Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell-cell communication and tumor-microenvironment cross talk, specifically in ...
Juan Lu, Qi-Hui Liu, Fan Wang, Jia-Jie Tan, Yue-Qin Deng, Xiao-Hong Peng, Xiong Liu, Bao Zhang, Xia Xu, Xiang-Ping Li   +9 more
doaj   +1 more source

The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer

Nature Communications
Younger premenopausal women are more prone to developing ovarian metastases (OM) of gastric cancer (GC) than metastases of other organs; however, the molecular mechanisms remain unclear. Here we perform single-cell RNA sequencing on 45 tumor samples from
Simeng Hu, Can Hu, Jingli Xu, Pengfei Yu, Li Yuan, Ziyu Li, Haohong Liang, Yanqiang Zhang, Jiahui Chen, Qing Wei, Shengjie Zhang, Litao Yang, Dan Su, Yian Du, Zhiyuan Xu, Fan Bai, Xiangdong Cheng   +16 more
doaj   +1 more source

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

Photochemistry and Photobiology, EarlyView.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira, Bruna Carolina Corrêa, Vanderlei Salvador Bagnato, Kate Cristina Blanco   +3 more
wiley   +1 more source

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer

Journal of Experimental & Clinical Cancer Research, 2010
The aims of this study were: to characterise and compare plasma concentrations of midkine (MDK) in normal healthy women with concentrations observed in women with ovarian cancer; and to establish and compare the performance of MDK with that of anterior ...
Edgell Tracey A, Rice Gregory E, Autelitano Dominic J   +2 more
doaj   +1 more source

Field‐Data‐Based Wind Turbine Reliability Modelling: Quantifying Effects of Operating Age, Design and Technological Development

Wind Energy, Volume 29, Issue 5, May 2026.
ABSTRACT As wind energy continues to expand, ensuring the reliability of wind turbines is critical for optimising operational efficiency and minimising downtime. Based on maintenance data from over 1,000 onshore and offshore wind turbines covering more than 4200 operating years, this study presents an analysis of wind turbine failure behaviour over ...
Julia Walgern, Fraser Anderson, Athanasios Kolios, Katharina Fischer   +3 more
wiley   +1 more source

Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition

Communications Biology
Numerous myofibroblasts are arisen from endothelial cells (ECs) through endothelial to mesenchymal transition (EndMT) triggered by TGF-β. However, the mechanism of ECs transforms to a different subtype, or whether there exists an intermediate state of ...
Cuidi Xu, Juntao Chen, Lifei Liang, Siyue Chen, Xinhao Niu, Ruirui Sang, Cheng Yang, Ruiming Rong   +7 more
doaj   +1 more source