Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression [PDF]
Advanced ScienceCholesterol metabolism influences prostate cancer (PCa) progression, especially by affecting the tumor microenvironment. The present study demonstrated that cancer cell‐intrinsic cholesterol promoted the S‐palmitoylation of specificity protein 1 (SP1 ...
Shirong Peng +12 more
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Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina [PDF]
Neural Development, 2012 Background Midkine is a small heparin binding growth factor expressed in numerous tissues during development. The unique midkine gene in mammals has two paralogs in zebrafish: midkine-a (mdka) and midkine-b (mdkb).
Luo Jing +5 more
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Premenopausal serum midkine levels and risk of estrogen receptor positive breast cancer: a prospective, nested case–control study [PDF]
Breast Cancer ResearchBackground Midkine is a heparin-binding growth factor that is overexpressed in most human malignancies, including breast cancer. While elevated midkine levels have been associated with tumor progression and aging, its role as a predictive biomarker for ...
Pengze Yan +7 more
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Midkine promotes PDGF‐BB‐induced proliferation, migration, and glycolysis of airway smooth muscle cells via the PI3K Akt pathway [PDF]
Physiological ReportsAirway smooth muscle cell (ASMC) dysfunction drives airway remodeling in asthma, yet the molecular mediators remain incompletely defined. Midkine, a pleiotropic growth factor, has emerged as a potential regulator of inflammatory and proliferative ...
Yongtian Xu +3 more
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Serum Midkine as a Potential Biomarker Associated with Disease Severity and Remodeling-Related Mediators in Children with Asthma [PDF]
Journal of Asthma and AllergyYongtian Xu,* Lixia Zhao,* Yingying Mi, Yi Ge, Yanfang Guo Department of Pediatrics, Shanghai University of Medicine and Health Science Affiliated Gongli Hospital, Shanghai, People’s Republic of China*These authors contributed ...
Xu Y, Zhao L, Mi Y, Ge Y, Guo Y
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EBioMedicine, 2018 Midkine is a pleiotropic factor, which is involved in angiogenesis. However, its mode of action in this process is still ill defined. The function of midkine in arteriogenesis, the growth of natural bypasses from pre-existing collateral arteries ...
Manuel Lasch +2 more
exaly +3 more sources
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation [PDF]
Advanced ScienceStress is an established trigger of skin inflammation and disease flares; however, the mechanisms have remained unclear. Here, using human data, mechanistic exploration, and single‐cell RNA sequencing in mouse models of skin inflammation under stress ...
Zhiguo Li +18 more
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A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche [PDF]
Cell RegenerationThe interaction between hematopoietic stem and progenitor cell (HSPC) and its vascular niche is essential for supporting the homeostasis and reconstitution of hematopoietic system in adult bone marrow (BM), but a comprehensive atlas covering this HSPC ...
Lan-Yue Ma +12 more
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Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis [PDF]
BiomedicinesBackground/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear.
Suna Aydin +7 more
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Multi-Component Analysis of Protein- and DNA-Coated Magnetic Nanoparticles Using Electrochemical Impedance Spectroscopy with Interdigitated Electrode Sensors [PDF]
BioengineeringThe characterization of cancer and other diseases can be aided by the development of reusable electrochemical sensors that provide broad biomarker expression information in real time. We describe an interdigitated electrode (IDE) sensor array that can be
Kestley Lutey +8 more
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