Results 1 to 10 of about 6,033 (210)

Pleiotrophin and metabolic disorders: insights into its role in metabolism [PDF]

Frontiers in Endocrinology, 2023
Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known
Cristina Ballesteros-Pla, MarÍa G SÁnchez, Maria P Ramos-Alvarez   +2 more
exaly   +4 more sources

Expression analysis of macrodactyly identifies pleiotrophin upregulation. [PDF]

PLoS ONE, 2012
Macrodactyly is a rare family of congenital disorders characterized by the diffuse enlargement of 1 or more digits. Multiple tissue types within the affected digits are involved, but skeletal patterning and gross morphological features are preserved. Not
Frank H Lau, Fang Xia, Adam Kaplan, Felecia Cerrato, Arin K Greene, Amir Taghinia, Chad A Cowan, Brian I Labow   +7 more
doaj   +14 more sources

Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus [PDF]

Frontiers in Cellular Neuroscience, 2015
Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
Celia eGonzález-Castillo, Daniel eOrtuño-Sahagún, Carolina eGuzmán-Brambila, Mercè ePalllàs, Argelia Esperanza Rojas-Mayorquin   +4 more
doaj   +3 more sources

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome [PDF]

Cell Reports
Summary: Neuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Here, we identify downregulation of pleiotrophin, a secreted molecule enriched in astrocytes, as a major contributor to ...
Ashley N. Brandebura, Adrien Paumier, Quinn N. Asbell, Tao Tao, Mariel Kristine B. Micael, Sherlyn Sanchez, Nicola J. Allen   +6 more
doaj   +2 more sources

Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis [PDF]

Biomedicines
Background/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear.
Suna Aydin, İsmail Polat, Kevser Tural, Nurullah Duger, Kader Ugur, İbrahim Sahin, Suleyman Aydin, Do-Youn Lee   +7 more
doaj   +2 more sources

A Pleiotrophin C-terminus peptide induces anti-cancer effects through RPTPβ/ζ

Molecular Cancer, 2010
Background Pleiotrophin, also known as HARP (Heparin Affin Regulatory Peptide) is a growth factor expressed in various tissues and cell lines. Pleiotrophin participates in multiple biological actions including the induction of cellular proliferation ...
Apostolos Polykratis, Jean Delbe, Jose Courty   +2 more
exaly   +3 more sources

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions [PDF]

Frontiers in Genetics
Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors.
María Aránzazu Penedo, María Aránzazu Penedo, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Esther Gramage, Esther Gramage, Esther Gramage, Gonzalo Herradón, Gonzalo Herradón, Gonzalo Herradón   +9 more
doaj   +2 more sources

Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats

Molecular Neurodegeneration, 2011
Background Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients.
Irene Taravini, Mariela Chertoff, Eduardo G Cafferata   +2 more
exaly   +3 more sources

Midkine and pleiotrophin in glioma: From mechanistic insights to therapeutic potential [PDF]

Neoplasia: An International Journal for Oncology Research
Midkine (MK) and pleiotrophin (PTN) are heparin-binding cytokines with growth factor properties that play essential roles in central nervous system development and tissue repair. Through pleiotropic, receptor-mediated signaling, they regulate fundamental
Mieszko Lachota, Katarzyna Zielniok, Radosław Zagożdżon   +2 more
doaj   +2 more sources

Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice [PDF]

Frontiers in Pharmacology
Alzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different ...
Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María Del Pilar Ramos-Álvarez, Gonzalo Herradón, Marta Vicente-Rodríguez   +9 more
doaj   +2 more sources