Results 1 to 10 of about 3,583 (200)

Pleiotrophin and metabolic disorders: insights into its role in metabolism [PDF]

Frontiers in Endocrinology, 2023
Pleiotrophin (PTN) is a cytokine which has been for long studied at the level of the central nervous system, however few studies focus on its role in the peripheral organs. The main aim of this review is to summarize the state of the art of what is known
Maria G Sanchez, Agata Zuccaro, Julio Sevillano   +2 more
exaly   +4 more sources

Pleiotrophin in Mammary Gland Development and Breast Cancer: A Comprehensive Review of the Evidence [PDF]

Cells
Pleiotrophin (PTN), a heparin-binding growth factor with potent mitogenic and angiogenic activity, has emerged as a key regulator of mammary gland biology and a potential driver of breast cancer progression. This review integrates current evidence on PTN’
Arianna S. Gholami, Ciara N. Walsh, Jean McBryan   +2 more
doaj   +2 more sources

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome [PDF]

Cell Reports
Summary: Neuronal dendrite patterning and synapse formation are tightly regulated during development to promote proper connectivity. Here, we identify downregulation of pleiotrophin, a secreted molecule enriched in astrocytes, as a major contributor to ...
Ashley N. Brandebura, Adrien Paumier, Quinn N. Asbell, Tao Tao, Mariel Kristine B. Micael, Sherlyn Sanchez, Nicola J. Allen   +6 more
doaj   +2 more sources

Direct Relationship Between Heparin Binding to Midkine and Pleiotrophin and the Development of Acute Deep Vein Thrombosis [PDF]

Biomedicines
Background/Objectives: The underlying molecular mechanisms of deep vein thrombosis (DVT), which continues to be a major global public health concern, remain unclear.
Suna Aydin, İsmail Polat, Kevser Tural, Nurullah Duger, Kader Ugur, İbrahim Sahin, Suleyman Aydin, Do-Youn Lee   +7 more
doaj   +2 more sources

Ethanol-induced changes in neurotrophic and immune genes are regulated by receptor-type protein tyrosine phosphatase β/ζ (RPTPβ/ζ) and microglial-neuronal interactions [PDF]

Frontiers in Genetics
Microglial cells are key mediators of ethanol-induced neuroinflammation through the release of proinflammatory cytokines and activation of Toll-like receptors.
María Aránzazu Penedo, María Aránzazu Penedo, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Esther Gramage, Esther Gramage, Esther Gramage, Gonzalo Herradón, Gonzalo Herradón, Gonzalo Herradón   +9 more
doaj   +2 more sources

Midkine and pleiotrophin in glioma: From mechanistic insights to therapeutic potential [PDF]

Neoplasia: An International Journal for Oncology Research
Midkine (MK) and pleiotrophin (PTN) are heparin-binding cytokines with growth factor properties that play essential roles in central nervous system development and tissue repair. Through pleiotropic, receptor-mediated signaling, they regulate fundamental
Mieszko Lachota, Katarzyna Zielniok, Radosław Zagożdżon   +2 more
doaj   +2 more sources

Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice [PDF]

Frontiers in Pharmacology
Alzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different ...
Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María Del Pilar Ramos-Álvarez, Gonzalo Herradón, Marta Vicente-Rodríguez   +9 more
doaj   +2 more sources

Beyond Amyloid: Targeting Co-Aggregating Proteins and Targeted Degradation Strategies in Alzheimer’s Disease [PDF]

Biomedicines
Alzheimer’s disease (AD) involves a constellation of molecular processes that extend well beyond amyloid-β (Aβ) accumulation. Recent anti-amyloid antibodies provide limited clinical benefits, highlighting the need for additional strategies due to their ...
Martina Monaco, Alessandra Pinto, Massimo Grilli   +2 more
doaj   +2 more sources

Association of serum pleiotrophin levels with acute coronary syndrome

International Journal of the Cardiovascular Academy, 2022
Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain.
Funda Basyigit, Orhan Karayigit, Serdar Gokhan Nurkoc, Serkan Duyuler, Pinar Turker Duyuler   +4 more
doaj   +1 more source

Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS

Biomedicines, 2023
Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ.
María Rodríguez-Zapata, Milagros Galán-Llario, Héctor Cañeque-Rufo, Julio Sevillano, María Gracia Sánchez-Alonso, José M. Zapico, Marcel Ferrer-Alcón, María Uribarri, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Gonzalo Herradón, Carmen Pérez-García, Esther Gramage   +12 more
doaj   +1 more source