Results 21 to 30 of about 6,033 (210)
PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior [PDF]
Nature CommunicationsMania is a complex psychiatric disease characterized by hyperactivity, elevated mood and reduced anxiety. Despite extensive studies on the mechanism of the manic episodes, the molecular targets that control manic pathogenesis remain largely unclear. Here,
Hongwon Kim +7 more
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Pleiotrophin fights Brd2 for neuronal differentiation
Neural Regeneration Research, 2015 Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucía, Spain, grant number P12-CTS-2064.
Pablo Garcia-Gutierrez +1 more
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Association of serum pleiotrophin levels with acute coronary syndrome
International Journal of the Cardiovascular Academy, 2022 Background and Aim: Pleiotrophin (PTN) is known as a multifunctional cytokine and a neurite outgrowth-promoting factor and appears as an angiogenic response to numerous processes such as ischemic injury affecting a region of the heart and the brain.
Funda Basyigit +4 more
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Biomedicines, 2023 Binge drinking during adolescence increases the risk of alcohol use disorder, possibly by involving alterations of neuroimmune responses. Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ.
María Rodríguez-Zapata +12 more
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Pleiotrophin-Loaded Mesoporous Silica Nanoparticles as a Possible Treatment for Osteoporosis
Pharmaceutics, 2023 Osteoporosis is the most common type of bone disease. Conventional treatments are based on the use of antiresorptive drugs and/or anabolic agents. However, these treatments have certain limitations, such as a lack of bioavailability or toxicity in non ...
Daniel Lozano +6 more
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Pleiotrophin Expression during Odontogenesis [PDF]
Journal of Histochemistry & Cytochemistry, 2012 Pleiotrophin (PTN) is an extracellular matrix–associated growth factor and chemokine expressed in mesodermal and ectodermal cells. It plays an important role in osteoblast recruitment and differentiation. There is limited information currently available about PTN expression during odontoblast differentiation and tooth formation, and thus the authors ...
Heidi, Erlandsen +8 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on PTN (pleiotrophin), with data on DNA, on the protein encoded, and where the gene is implicated.
Pantazaka, E, Papadimitriou, E
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Interactions of Pleiotrophin with a Structurally Defined Heparin Hexasaccharide
Biomolecules, 2021 Pleiotrophin (PTN) is a potent cytokine that plays an important role in neural generation, angiogenesis, inflammation, and cancers. Its interactions with the polysaccharide glycosaminoglycan (GAG) are crucial to PTN’s biological activities. In this study,
Eathen O. Ryan +3 more
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Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex
Cells, 2023 During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species.
Margarita Belem Santana-Bejarano +7 more
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Pleiotrophin regulates microglia-mediated neuroinflammation [PDF]
Journal of Neuroinflammation, 2017 Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in different disorders characterized by overt neuroinflammation such as neurodegenerative diseases, drug addiction, traumatic injury, and ischemia. In the present work, we have explored whether PTN modulates neuroinflammation and if Toll-like receptor 4 (TLR4), crucial in the ...
Fernández-Calle, Rosalía +8 more
openaire +2 more sources