Results 21 to 30 of about 3,583 (200)
The effects of pleiotrophin in proliferative diabetic retinopathy. [PDF]
PLoS ONE, 2015 Pleiotrophin (PTN), a secreted, multifunctional cytokine, is involved in angiogenic, fibrotic and neurodegenerative diseases. However, little is known about its effects on diabetic retinopathy, a neurovascular disease.
Xuemei Zhu +11 more
doaj +4 more sources
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer. [PDF]
PLoS ONE, 2016 BACKGROUND:Thyroid nodules are common, and approximately 5% of these nodules are malignant. Pleiotrophin (PTN) is a heparin-binding growth factor which is overexpressed in many cancers.
Youn Hee Jee +9 more
doaj +4 more sources
The role of pleiotrophin and β-catenin in fetal lung development
Respiratory Research, 2010 Mammalian lung development is a complex biological process, which is temporally and spatially regulated by growth factors, hormones, and extracellular matrix proteins.
Weng Tingting, Liu Lin
doaj +2 more sources
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation. [PDF]
Glia– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Hammond BP +4 more
europepmc +2 more sources
Pleiotrophin-Loaded Mesoporous Silica Nanoparticles as a Possible Treatment for Osteoporosis
Pharmaceutics, 2023 Osteoporosis is the most common type of bone disease. Conventional treatments are based on the use of antiresorptive drugs and/or anabolic agents. However, these treatments have certain limitations, such as a lack of bioavailability or toxicity in non ...
Daniel Lozano +6 more
doaj +1 more source
Pleiotrophin fights Brd2 for neuronal differentiation
Neural Regeneration Research, 2015 Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucía, Spain, grant number P12-CTS-2064.
Pablo Garcia-Gutierrez +1 more
doaj +4 more sources
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex
Cells, 2023 During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species.
Margarita Belem Santana-Bejarano +7 more
doaj +1 more source
Cells, 2020 Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration.
Yu-Hee Kim +7 more
doaj +1 more source
Frontiers in Neurology, 2021 Heparin-binding growth-associated molecule (pleiotrophin) is a neurite outgrowth-promoting secretory protein that lines developing fiber tracts in juvenile CNS (central nervous system).
Natalia Kulesskaya +6 more
doaj +1 more source
Relationship Between Serum Concentrations of the Growth Factor Pleiotrophin and Pleiotrophin-Positive Tumors [PDF]
JNCI: Journal of the National Cancer Institute, 1998 Growth factors produced by tumor cells are essential for tumor expansion and may be useful in monitoring tumor progression or therapeutic efficacy if the factors are released into the circulation. In this study, we measured serum levels of pleiotrophin, a secreted heparin-binding growth and angiogenesis factor, in mice bearing human tumor xenografts to
B, Souttou +7 more
openaire +2 more sources