Cells, 2020 Cotransplantation of mesenchymal stem cells (MSCs) with hematopoietic stem cells (HSCs) has been widely reported to promote HSC engraftment and enhance marrow stromal regeneration.
Yu-Hee Kim +7 more
doaj +1 more source
Frontiers in Neurology, 2021 Heparin-binding growth-associated molecule (pleiotrophin) is a neurite outgrowth-promoting secretory protein that lines developing fiber tracts in juvenile CNS (central nervous system).
Natalia Kulesskaya +6 more
doaj +1 more source
Relationship Between Serum Concentrations of the Growth Factor Pleiotrophin and Pleiotrophin-Positive Tumors [PDF]
JNCI: Journal of the National Cancer Institute, 1998 Growth factors produced by tumor cells are essential for tumor expansion and may be useful in monitoring tumor progression or therapeutic efficacy if the factors are released into the circulation. In this study, we measured serum levels of pleiotrophin, a secreted heparin-binding growth and angiogenesis factor, in mice bearing human tumor xenografts to
B, Souttou +7 more
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New molecular mediators in tumor angiogenesis [PDF]
, 2007 Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Beecken, Wolf-Dietrich +2 more
core +1 more source
Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration [PDF]
, 2014 Introduction : The degenerate intervertebral disc (IVD) becomes innervated by sensory nerve fibres, and vascularised by blood vessels. This study aimed to identify neurotrophins, neuropeptides and angiogenic factors within native IVD tissue and to ...
Binch, Abbie L.A. +6 more
core +2 more sources
ESF-EMBO symposium "molecular biology and innovative therapies in sarcomas of childhood and adolescence" Sept 29–Oct 4, Polonia Castle Pultusk, Poland [PDF]
, 2013 Rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) are among the most common pediatric sarcomas (Arndt et al., 2012). Despite sarcomas representing a highly heterogeneous group of tumors, ES and alveolar RMS (ARMS) typically share one common genetic ...
Fulda, Simone +3 more
core +2 more sources
Neuroinflammation and Its Resolution: From Molecular Mechanisms to Therapeutic Perspectives [PDF]
, 2020 Neuroinflammation, the complex immune response of the central nervous system (CNS), when sustained, is a common denominator in the etiology and course of all major neurological diseases, including neurodevelopmental, neurodegenerative, and psychiatric ...
Berwian +11 more
core +2 more sources
Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma
Pharmaceuticals, 2011 RNA interference (RNAi) allows the specific knockdown of tumor relevant genes. To induce RNAi, the delivery of small interfering RNAs (siRNAs) is of crucial importance. This is particularly challenging for their therapeutic applications in vivo.
Achim Aigner +3 more
doaj +1 more source
The expression and function of midkine in the vertebrate retina [PDF]
, 2014 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102704/1/bph12495 ...
Cameron DA +8 more
core +1 more source
Domain Structure of Pleiotrophin Required for Transformation [PDF]
Journal of Biological Chemistry, 1999 The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors. The product of the Ptn gene is a secreted 136-amino acid heparin binding cytokine with distinct lysine-rich clusters within both the N- and C-terminal domains.
N, Zhang, R, Zhong, T F, Deuel
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