Results 31 to 40 of about 3,583 (200)
Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma
Pharmaceuticals, 2011 RNA interference (RNAi) allows the specific knockdown of tumor relevant genes. To induce RNAi, the delivery of small interfering RNAs (siRNAs) is of crucial importance. This is particularly challenging for their therapeutic applications in vivo.
Achim Aigner +3 more
doaj +1 more source
ALK activation, ligands and therapeutic targets in glioblastoma and other cancers
Frontiers in Oncology, 2012 The intracellular anaplastic lymphoma kinase (ALK) fragment shows striking homology with members of the insulin receptor family and was initially identified as an oncogenic fusion protein resulting from a translocation in lymphoma and more recently in a ...
Anton eWellstein
doaj +1 more source
Expression of VEGF and pleiotrophin in deer antler [PDF]
The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006 AbstractDeer antlers represent a unique model of mammalian regeneration in that they cast and fully regenerate every year. The deer antler thus provides a fascinating model of both rapid angiogenesis and chondrogenesis and the opportunity to investigate unique growth regulatory processes. One such phenomenon is the presence of vascularized cartilage in
Dawn E, Clark +2 more
openaire +2 more sources
International Journal of the Cardiovascular Academy, 2023 Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI)
Serdar Gökhan Nurkoç +4 more
doaj +1 more source
Loss of parafollicular cells during gravitational changes (microgravity, hypergravity) and the secret effect of pleiotrophin. [PDF]
PLoS ONE, 2012 It is generally known that bone loss is one of the most important complications for astronauts who are exposed to long-term microgravity in space. Changes in blood flow, systemic hormones, and locally produced factors were indicated as important elements
Elisabetta Albi +8 more
doaj +1 more source
The effect of pleiotrophin signaling on adipogenesis
FEBS Letters, 2007 Pleiotrophin (PTN) plays diverse roles in cell growth and differentiation. In this investigation, we demonstrate that PTN plays a negative role in adipogensis and that glycogen synthase kinase 3β (GSK‐3β) and β‐catenin are involved in the regulation of PTN‐mediated preadipocyte differentiation.
Gu, Dayong +7 more
openaire +2 more sources
Pleiotrophin regulates microglia-mediated neuroinflammation [PDF]
Journal of Neuroinflammation, 2017 Pleiotrophin (PTN) is a cytokine found highly upregulated in the brain in different disorders characterized by overt neuroinflammation such as neurodegenerative diseases, drug addiction, traumatic injury, and ischemia. In the present work, we have explored whether PTN modulates neuroinflammation and if Toll-like receptor 4 (TLR4), crucial in the ...
Fernández-Calle, Rosalía +8 more
openaire +2 more sources
, 2015 Glioblastomas are aggressive astrocytomas characterized by endothelial cell proliferation and abnormal vasculature, which can cause brain edema and increase patient morbidity.
Forsberg, Karin Nilsson, +17 more
core +2 more sources
Frontiers in Immunology, 2020 In a previous study, we have reported an increased plasma midkine (MK) and pleiotrophin (PTN) concentrations in patients with systemic lupus erythematosus (SLE) and the increase in MK and PTN associated with inflammatory cytokines interleukin (IL)-17 ...
Peng Wang +11 more
doaj +1 more source
Domain Structure of Pleiotrophin Required for Transformation [PDF]
Journal of Biological Chemistry, 1999 The pleiotrophin (PTN) gene (Ptn) is a potent proto-oncogene that is highly expressed in many primary human tumors and constitutively expressed in cell lines derived from these tumors. The product of the Ptn gene is a secreted 136-amino acid heparin binding cytokine with distinct lysine-rich clusters within both the N- and C-terminal domains.
N, Zhang, R, Zhong, T F, Deuel
openaire +2 more sources