Results 51 to 60 of about 3,583 (200)
Frontiers in Pharmacology, 2019 Inflammation is a common factor of pathologies such as obesity, type 2 diabetes or neurodegenerative diseases. Chronic inflammation is considered part of the pathogenic mechanisms of different disorders associated with aging.
Gonzalo Herradon +2 more
doaj +1 more source
Reprogramming the Immune Landscape of Inflammatory Breast Cancer
Advanced Science, EarlyView.Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez +3 more
wiley +1 more source
Neural precursor-derived pleiotrophin mediates subventricular zone invasion by glioma
, 2017 All raw data for Qin et al., Neural precursor-derived pleiotrophin mediates subventricular zone invasion by glioma, excluding raw sequencing data, which is deposited in GEO and The European Genome-phenome Archive (EGA ...
Qin, E
core +2 more sources
Antibody Characterization Report for Pleiotrophin
, 2022 Head-to-head comparison of available commercial antibodies against Pleiotrophin by immunoblot (Western blot) and immunoprecipitation on culture media. Work reported in this report was supported in part by the Emory-Sage-SGC TREAT-AD center established by the National Institutes of Aging under award number U54AG065187.
Ayoubi, Riham +3 more
openaire +3 more sources
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
Frontiers in Bioengineering and Biotechnology, 2019 A fast re-endothelialization, along with the inhibition of neointima hyperplasia, are crucial to reduce the failure of vascular bypass grafts. Implants modifications with molecules capable of speeding up the re-endothelialization process have been ...
Francesco Copes +7 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) shows clinical and molecular heterogeneity, and cardiovascular (CV) complications and lupus nephritis (LN) remain leading causes of morbidity and mortality. This study investigated whether omic profiling can reveal molecular endotypes linked to these outcomes.
Tomás Cerdó +84 more
wiley +1 more source
Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, EarlyView.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
Pleiotrophin is a neurotrophic factor for spinal motor neurons [PDF]
Proceedings of the National Academy of Sciences, 2007 Regeneration in the peripheral nervous system is poor after chronic denervation. Denervated Schwann cells act as a “transient target” by secreting growth factors to promote regeneration of axons but lose this ability with chronic denervation. We discovered that the mRNA for pleiotrophin (PTN) was highly up-regulated in acutely denervated distal sciatic
Ruifa, Mi, Weiran, Chen, Ahmet, Höke
openaire +2 more sources
Cancer Science, EarlyView.Spatial transcriptomics and bulk RNA‐seq data analysis revealed the molecular characteristics of invasive lobular carcinoma (ILC). ILC was classified into three clusters: proliferative, immunoreactive, and stromal‐rich, with different prognoses. ABSTRACT Invasive lobular carcinoma (ILC) is a special type of breast cancer.
Momoko Tokura +9 more
wiley +1 more source