Results 71 to 80 of about 3,583 (200)

Amniotic fluid midkine and pleiotrophin concentrations correlated with each other.

, 2016
Midkine concentrations were positively correlated with pleiotrophin concentrations in amniotic fluid (R = 0.6, P < 0.001), using diagnostic category as a covariate.
Gai Yan (2614453), Youn Hee Jee (2512453), Yael Lebenthal (2614447), Anton Wellstein (127138), Roberto Romero (19224), Piya Chaemsaithong (2614450), Ivana Peran (215875), Jeffrey Baron (516003)   +7 more
core   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, Volume 13, Issue 27, 13 May 2026.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis. [PDF]

PLoS ONE, 2014
Pleiotrophin (PTN) is a growth factor present in the extracellular matrix of the growth plate during bone development and in the callus during bone healing.
Thibault Bouderlique, Emilie Henault, Angelique Lebouvier, Guilhem Frescaline, Phillipe Bierling, Helene Rouard, José Courty, Patricia Albanese, Nathalie Chevallier   +8 more
doaj   +1 more source

Identification of receptors and function - domain study of pleiotrophin on cell migration

, 2009
Pleiotrophin is a growth factor that among other functions, plays a significant role on tumor growth and angiogenesis. Our group has previously shown that pleiotrophin is able to induce migration of endothelial cells through binding to its receptor ...
Μικέλης, Κωνσταντίνος-Μάριος, Mikelis, Constantinos-Marios   +1 more
core   +1 more source

Excitatory neurons and astrocytes‐specific dysregulation and aberrant interactions are vulnerable to FCDI as suggested by single‐cell spatial transcriptomics

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang, Qihang Zou, Yingying Liu, Yinchao Li, Yubao Fang, Tiancai Huang, Jiabin Yu, Lisen Sui, Dezhi Cao, Liemin Zhou   +9 more
wiley   +1 more source

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

Nature Communications, 2017
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in ...
Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N Rich, Shideng Bao, Xiu-Wu Bian   +26 more
doaj   +1 more source

Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance

Frontiers in Pharmacology
Alzheimer’s disease (AD) is the most common cause of dementia. Pleiotrophin (PTN) is a neurotrophic factor relevant for central nervous system repair, neuron differentiation and survival. It is upregulated in different neuroinflammatory conditions.
Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Marta Vicente-Rodríguez, Gonzalo Herradón   +9 more
doaj   +1 more source

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao, Li Zou, Yao Yao, Changling Liu   +3 more
wiley   +1 more source

Identification of novel heparin-releasable proteins, as well as the cytokines midkine and pleiotrophin, in human postheparin plasma.

, 1993
The heparin-releasable proteins are a group of proteins that are targeted to the endothelial surface by attachment to glycosaminoglycans and may have functions specific to the endothelium-blood interface. In this study, heparin-affinity chromatography of
W F Novotny, T Maffi, R L Mehta, P G Milner   +3 more
core   +1 more source

Study on the Potential Molecular Mechanism of Keloid Disease Associated With Single Cell Combined Mendelian Randomization

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Keloids are pathological scars with incompletely understood pathogenesis. This study aims to identify the key genes and regulatory networks potentially involved in keloid formation by integrating single‐cell transcriptomics (scRNA‐seq), protein quantitative trait loci (pQTL), Mendelian randomization (MR) analyses, colocalization ...
Hui‐Hui Wu, Yong‐Xia Meng, Juan‐Hua Liu, Di‐Qing Luo, Mu‐Kai Chen, Yu‐Kun Zhao   +5 more
wiley   +1 more source