Results 81 to 90 of about 3,583 (200)

Effects of Pleiotrophin on endothelial and inflammatory cells: Pro-angiogenic and anti-inflammatory properties and potential role for vascular bio-prosthesis endothelialization

, 2015
Purpose: One of the limitations emerged with both synthetic and degradable vascular grafts is the lack of endothelialization after implantation that is known to be the main reason leading to unfavourable outcomes.
MURA, MARZIA, Mambrini, Simone, PALMIERI, DANIELA, PALOMBO, DOMENICO   +3 more
core   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, Volume 13, Issue 16, 18 March 2026.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4‐ and VEGF‐mediated pathways: insights from a vascular to mixed‐type dementia model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive impairment; however, its underlying mechanisms remain poorly understood. METHODS We investigated CCH‐induced glymphatic dysfunction and neurodegeneration in amyloid precursor protein (APP)/presenilin 1 (PS1) and wild‐type mice.
Jia‐Hung Chen, Ching‐Wen Chang, You‐Yin Chen, Chih‐Hao Yang, Wen‐Bin Yang, Yi‐Chen Hsieh, Yao‐Wen Liang, Ssu‐Ju Li, Chaur‐Jong Hu   +8 more
wiley   +1 more source

Image_2_Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.jpeg

, 2022
Astrocytes are the most abundant glial cells in the central nervous system (CNS) with the capacity to sense and react to injury and inflammatory events. While it has been widely documented that astrocytes can exert tissue-degenerative functions, less is ...
Ulrike Naumann (123144), Lena Lößlein (11894705), Daniel Farrenkopf (11894708), Thanos Tsaktanis (11894714), Oliver Vandrey (11894711), Mathias Linnerbauer (11894702), Veit Rothhammer (357525)   +6 more
core   +1 more source

Chronic myelogenous leukemia stem cells require cell-autonomous pleiotrophin signaling [PDF]

, 2020
Tyrosine kinase inhibitors (TKIs) induce molecular remission in the majority of patients with chronic myelogenous leukemia (CML), but the persistence of CML stem cells hinders cure and necessitates indefinite TKI therapy.
Roos, Martina, Chute, John P, Pang, Amara, Sasine, Joshua P, Termini, Christina M, Suh, Hyung, Schiller, Gary, Sapparapu, Gopal, Kan, Jenny, Zhang, Yurun, Kim, Mindy, Zhao, Liman, Himburg, Heather A, Schlussel, Lauren, Fang, Tiancheng, Bowers, Peter M   +15 more
core   +1 more source

Bone turnover in wild type and pleiotrophin-transgenic mice housed for three months in the International Space Station (ISS).

PLoS ONE, 2012
Bone is a complex dynamic tissue undergoing a continuous remodeling process. Gravity is a physical force playing a role in the remodeling and contributing to the maintenance of bone integrity.
Sara Tavella, Alessandra Ruggiu, Alessandra Giuliani, Francesco Brun, Barbara Canciani, Adrian Manescu, Katia Marozzi, Michele Cilli, Delfina Costa, Yi Liu, Federica Piccardi, Roberta Tasso, Giuliana Tromba, Franco Rustichelli, Ranieri Cancedda   +14 more
doaj   +1 more source

Midkine Overexpression Promotes Functional Recovery After Spinal Cord Injury by Enhancing Microglial Efferocytosis Via LRP‐1

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Midkine (MDK) promotes functional recovery after spinal cord injury by enhancing microglial efferocytosis, reducing neuroinflammation, and decreasing neuronal apoptosis. Overexpression of MDK activates the AKT/mTOR pathway, upregulates LRP‐1 and BDNF, and drives microglia toward an anti‐inflammatory phenotype.
Yu Wang, Lu Fang, Chenyuan Zhai, Jili Cai, Xiangzhe Li, Lijuan Zong, Yao Geng, Chenchen Zhu, Cheng Sun, Manyu Dong, Yilun Qian, Yan Liu, Ying Huang, Zun Wang, Tong Wang, Wen‐Tao Liu, Qi Wu   +16 more
wiley   +1 more source

Image_3_Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation.jpeg

, 2022
Astrocytes are the most abundant glial cells in the central nervous system (CNS) with the capacity to sense and react to injury and inflammatory events. While it has been widely documented that astrocytes can exert tissue-degenerative functions, less is ...
Ulrike Naumann (123144), Lena Lößlein (11894705), Daniel Farrenkopf (11894708), Thanos Tsaktanis (11894714), Oliver Vandrey (11894711), Mathias Linnerbauer (11894702), Veit Rothhammer (357525)   +6 more
core   +1 more source

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

Pleiotrophin triggers inflammation and increased peritoneal permeability leading to peritoneal fibrosis

, 2012
Long-term peritoneal dialysis induces peritoneal fibrosis with submesothelial fibrotic tissue. Although angiogenesis and inflammatory mediators are involved in peritoneal fibrosis, precise molecular mechanisms are undefined.
Kato, Yukiko, Yukiko Kato, Takashi Muramatsu, Akira Ishii, Hisako Muramatsu, Ishii, Akira, Kiyoshi Mori, Koga, Kenichi, Sugawara, Akira, Nakao, Kazuwa, Keita P. Mori, Shoko Ohno, Kawanishi, Tomoko, Akira Sugawara, Takashige Kuwabara, Kasahara, Masato, Ogawa, Yoshihisa, Kuwabara, Takashige, Yoshihisa Ogawa, Kenichi Koga, Hideki Yokoi, Tomoko Kawanishi, Masato Kasahara, Naohiro Toda, Mori, Kiyoshi, Yokoi, Hideki, Hirotaka Imamaki, Muramatsu, Hisako, Mori, Keita P., Mukoyama, Masashi, Ohno, Shoko, Muramatsu, Takashi, Kazuwa Nakao, Masashi Mukoyama, Toda, Naohiro, Imamaki, Hirotaka   +35 more
core   +1 more source