Results 81 to 90 of about 6,033 (210)

Pleiotrophin commits human bone marrow mesenchymal stromal cells towards hypertrophy during chondrogenesis. [PDF]

PLoS ONE, 2014
Pleiotrophin (PTN) is a growth factor present in the extracellular matrix of the growth plate during bone development and in the callus during bone healing.
Thibault Bouderlique, Emilie Henault, Angelique Lebouvier, Guilhem Frescaline, Phillipe Bierling, Helene Rouard, José Courty, Patricia Albanese, Nathalie Chevallier   +8 more
doaj   +1 more source

The systemic angiogenic response during bone healing [PDF]

, 2018
Introduction: Angiogenesis is known to be a critical and closely regulated step during bone formation and fracture healing driven by a complex interaction of various cytokines.
Henle, Philipp, Pufe, Thomas, Varoga, Deike, Weiss, Stefan, Zimmermann, Gerald   +4 more
core  

Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration [PDF]

, 2018
Pleiotrophin (PTN) stimulates endothelial cell migration through binding to receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) and ανβ3 integrin.
A Bogush, A Hernandez, A Polykratis, AH Hawasli, C González-Castillo, C Heiss, C Marinaccio, C Mikelis, DH Ausprunk, E Contreras-Vallejos, E Lampropoulou, E Papadimitriou, E Papadimitriou, E Szabat, E Řezníčková, G Herradón, H Merk, H Pariser, H Yanagisawa, HJ Yeh, J Herzog, J Liebl, J Liebl, J Liebl, J Yao, JK Jin, K Meng, K Shah, K Shah, KO Lai, KP Sarker, L He, LJ Zhang, M Koutsioumpa, M Koutsioumpa, M Koutsioumpa, M Nikolic, MA Fousteris, MH Lee, MJ Xavier, MM Mandl, MR Hellmich, MR Sharma, N Franceschi De, N Mitsios, N Olmo del, ND Amin, S Tsirmoula, S Zhang, SB Weitensteiner, SS Sun, T Skillbäck, V Lalioti, Y Gao   +53 more
core   +2 more sources

Endogenous pleiotrophin and midkine regulate LPS-induced glial responses [PDF]

Neuroscience Letters, 2018
Pleiotrophin (PTN) and Midkine (MK) are two growth factors that modulate neuroinflammation. PTN overexpression in the brain prevents LPS-induced astrocytosis in mice but potentiates microglial activation. The modest astrocytic response caused by a low dose of LPS (0.5mg/kg) is blocked in the striatum of MK-/- mice whereas microglial response is ...
Rosalía, Fernández-Calle, Marta, Vicente-Rodríguez, Esther, Gramage, Carlos, de la Torre-Ortiz, Carmen, Pérez-García, María P, Ramos, Gonzalo, Herradón   +6 more
openaire   +2 more sources

Innate Immunity and Microbial Recognition in Reproduction: From Barrier Defense to Maternal–Fetal Tolerance

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Graphical abstract illustrating the barrier defense–tolerance framework of reproductive innate immunity. Across the female and male reproductive tracts and the maternal–fetal interface, epithelial barriers, innate sensors, immune cells, and microbial signals are integrated to preserve reproductive homeostasis.
Xianlin Rao, Li Zou, Yao Yao, Changling Liu   +3 more
wiley   +1 more source

Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

Nature Communications, 2017
Tumour-associated macrophages (TAMs) facilitate malignant growth of glioblastoma (GBM). Here, the authors show that TAMs support glioma stem cell renewal via paracrine signalling to the pleiotrophin receptor PTPRZ1 and that blocking this axis results in ...
Yu Shi, Yi-Fang Ping, Wenchao Zhou, Zhi-Cheng He, Cong Chen, Bai-Shi-Jiao Bian, Lin Zhang, Lu Chen, Xun Lan, Xian-Chao Zhang, Kai Zhou, Qing Liu, Hua Long, Ti-Wei Fu, Xiao-Ning Zhang, Mian-Fu Cao, Zhi Huang, Xiaoguang Fang, Xiuxing Wang, Hua Feng, Xiao-Hong Yao, Shi-Cang Yu, You-Hong Cui, Xia Zhang, Jeremy N Rich, Shideng Bao, Xiu-Wu Bian   +26 more
doaj   +1 more source

Study on the Potential Molecular Mechanism of Keloid Disease Associated With Single Cell Combined Mendelian Randomization

Journal of Cosmetic Dermatology, Volume 25, Issue 4, April 2026.
ABSTRACT Background Keloids are pathological scars with incompletely understood pathogenesis. This study aims to identify the key genes and regulatory networks potentially involved in keloid formation by integrating single‐cell transcriptomics (scRNA‐seq), protein quantitative trait loci (pQTL), Mendelian randomization (MR) analyses, colocalization ...
Hui‐Hui Wu, Yong‐Xia Meng, Juan‐Hua Liu, Di‐Qing Luo, Mu‐Kai Chen, Yu‐Kun Zhao   +5 more
wiley   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, Volume 13, Issue 16, 18 March 2026.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Molecular Study of Interactions between Hematopoietic Stem Cells and Stromal Cells [PDF]

, 2002
Multipotent hematopoietic stem cells (HSCs) are progenitors of all types of hematopoietic cells, and the efficient isolation and propagation of HSCs will significantly enhance our ability to manage many human disorders with bone marrow transplantation ...
Heard, Amanda, Kaiser, Chris, Lemischka, Ihor R., Li, Zhe, Lodish, Harvey F., Luo, Biao, Meng-Ling, Choong, Moore, Kateri, Yap, Miranda G.S.   +8 more
core