Results 61 to 70 of about 3,583 (200)
Targeting the PTN/PTPRZ1-ROS Pathway to Promote Bone Regeneration
BiomedicinesBackground: Osteoporosis is a global health problem that significantly decreases patients’ quality of life and causes tremendous medical burdens. Therefore, exploring effective targeting strategies for osteoporosis treatment is crucial.
Kai Zhao +6 more
doaj +1 more source
The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation. [PDF]
PLoS ONE, 2014 Midkine (MDK) and Pleiotrophin (PTN) are small heparin-binding cytokines with closely related structures. The Drosophila genome harbours two genes encoding members of the MDK/PTN family of proteins, known as miple1 and miple2.
Fredrik Hugosson +5 more
doaj +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
On the role of pleiotrophin and its receptors in development and angiogenesis
The International Journal of Developmental Biology, 2022 The secreted growth factor pleiotrophin (PTN) is expressed in all species and is evolutionarily highly conserved, suggesting that it plays a significant role in the regulation of important processes. The observation that it is highly expressed at early stages during development and in embryonic progenitor cells highlights a potentially important ...
Evangelia, Papadimitriou +5 more
openaire +3 more sources
Thirty Years of Autologous Platelet Concentrates: From Platelet‐Rich Plasma to Platelet‐Rich Fibrin
Journal of Periodontal Research, EarlyView.This review highlights the 30 years of evolution of APCs, with a focus on their clinical applications and recent technological advancements. ABSTRACT Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice.
Richard J. Miron +7 more
wiley +1 more source
, 2006 Osteoporose ist eine Krankheit, die in unserer Gesellschaft mit zunehmender Inzidenz auftritt. Derzeit stehen aber nur ungenügend Therapieverfahren zur Verfügung.
Behr, Katharina
core +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben +4 more
wiley +1 more source
, 2007 Pleiotrophin is a development-regulated cytokine and growth factor that can promote angiogenesis, cell proliferation, or differentiation, and it has been reported to have neovasculogenic effects in damaged heart.
Volkova, M +10 more
core +1 more source
A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, Volume 13, Issue 29, 22 May 2026.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Einfluss von Pleiotrophin auf das Wachstumsverhalten von Spiral Ganglion Neuronen
, 2020 Die sensorineurale Schwerhörigkeit unterliegt einem Verlust von Haarzellen und führt aufgrund dessen sekundär zur Degeneration von Spiralganglienneuronen.
Bertram, Sebastian Johannes (Dr. med.)
core