Results 41 to 50 of about 3,583 (200)
Methylcobalamin facilitates collateral sprouting of donor axons and innervation of recipient muscle in end-to-side neurorrhaphy in rats. [PDF]
PLoS ONE, 2013 Using ulnar nerve as donor and musculocutaneous nerve as recipient we found earlier that end-to-side neurorrhaphy resulted in weak functional reinnervation after lengthy survival.
Wen-Chieh Liao +3 more
doaj +1 more source
Astrocyte-Derived Pleiotrophin Mitigates Late-Stage Autoimmune CNS Inflammation
Frontiers in Immunology, 2022 Astrocytes are the most abundant glial cells in the central nervous system (CNS) with the capacity to sense and react to injury and inflammatory events. While it has been widely documented that astrocytes can exert tissue-degenerative functions, less is ...
Mathias Linnerbauer +6 more
doaj +1 more source
A Comparative Analysis of Erythropoietin and Carbamoylated Erythropoietin Proteome Profiles
Life, 2021 In recent years, erythropoietin (EPO) has emerged as a useful neuroprotective and neurotrophic molecule that produces antidepressant and cognitive-enhancing effects in psychiatric disorders.
Neeraj K. Tiwari +3 more
doaj +1 more source
Constitutive Pleiotrophin Deletion Results in a Phenotype with an Altered Pancreatic Morphology and Function in Old Mice. [PDF]
Int J Mol SciPleiotrophin (PTN) is crucial for embryonic development and pancreas organogenesis as it regulates metainflammation, metabolic homeostasis, thermogenesis, and glucose tolerance. Pleiotrophin deletion is associated with a lipodystrophic phenotype in which
Ballesteros-Pla C +11 more
europepmc +2 more sources
Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice [PDF]
, 2019 Aims/hypothesis Pleiotrophin, a developmentally regulated and highly conserved cytokine, exerts different functions including regulation of cell growth and survival.
vivente-rodriguez, marta +15 more
core +2 more sources
Cell Reports, 2023 Summary: Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging hippocampus remains to be elucidated.
Haoyang Li +12 more
doaj +1 more source
Pleiotrophin: Activity and mechanism
, 2020 Pleiotrophin (PTN) is a potent mitogenic cytokine with a high affinity for the polysaccharide glycosaminoglycan (GAG). Although it is most strongly associated with neural development during embryogenesis and the neonatal period, its expression has also been linked to a plethora of other physiological events including cancer metastasis, angiogenesis ...
openaire +3 more sources
Pleiotrophin as a central nervous system neuromodulator, evidences from the hippocampus
Frontiers in Cellular Neuroscience, 2015 Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the extracellular matrix, which has recently starting to attract attention as a significant neuromodulator with multiple neuronal functions during development.
Celia eGonzález-Castillo +4 more
doaj +1 more source
Advanced Science, EarlyView.CAF‐derived S1P activates the S1PR3‐JNK‐Jun signaling pathway, thereby transcriptionally upregulating MALL expression in cancer cells. MALL increases the cell‐surface abundance of SDC4 by promoting its recycling and restricting its lysosomal degradation, which in turn enhances RhoA‐p‐MLC2‐dependent amoeboid invasion and SDC4‐PTN axis‐mediated cancer ...
Wang Peng +16 more
wiley +1 more source
Pleiotrophin (PTN) immunostaining.
, 2012 DAPI = nuclear stain, PTN = antibody staining for pleiotrophin, Merge = composite image merging Brightfield, DAPI, and PTN channels. A) No PTN is seen in pediatric subcutaneous adipose tissue from Patient 7.
Adam Kaplan (146444) +7 more
core +1 more source